Carcinoma in situ of skin of eyelid, including canthus

CD2_INSITU_SKIN_EYELID

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D04.1&
  • Hospital discharge: ICD-9 2321
  • Cause of death: ICD-10 D04.1&
  • Cause of death: ICD-9 2321

2 out of 7 registries used, show all original rules.

87

4. Check minimum number of events

None

87

5. Include endpoints

None

87

6. Filter based on genotype QC (FinnGen only)

78

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D04
Name in latin
Carcinoma in situ cutis palpebrae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 78 34 44
Unadjusted period prevalence (%) 0.02 0.01 0.02
Median age at first event (years) 78.48 78.22 78.69

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
81
Matched controls
810
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D04.1
ICD-10 Finland
Carcinoma in situ: Skin of eyelid, including canthus
+∞
113.6
80
*
L57.0
ICD-10 Finland
Actinic keratosis
10.6
26.3
48
98
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
27.4
21.1
29
16
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
8.9
18.9
30
50
CBA10
NOMESCO Finland
Biopsy of eyelid
42.3
14.2
17
5
TQW99
NOMESCO Finland
Other minor procedure on skin
12.0
13.3
25
29
CBB50
NOMESCO Finland
Excision of lesion of eyelid and reconstruction using graft or flap
152.7
12.8
13
*
CBB30
NOMESCO Finland
Excision of lesion of eyelid
21.1
11.8
17
10
C44.11
ICD-10 Finland
Basocellular carcinoma of the skin of the eyelids including the corner of the eye
25.8
11.2
15
7
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
5.4
11.1
29
76
ZXC15
NOMESCO Finland
Use of photodynamic technique
18.0
10.0
15
10
D23.1
ICD-10 Finland
Benign neoplasm: Skin of eyelid, including canthus
13.1
9.9
17
16
S21
ICPC
Skin texture symptom/complaint
4.8
9.4
28
81
R23.8
ICD-10 Finland
Other and unspecified skin changes
4.3
9.3
35
121
ZXC50
NOMESCO Finland
Cryotherapy
8.9
8.5
18
25
C44.12
ICD-10 Finland
Spinocellular carcinoma of the skin of the eyelids including the corner of the eye
+∞
8.5
8
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
4.6
8.2
24
68
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
5.0
7.6
19
47
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
10.3
7.4
14
16
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
11.6
7.3
13
13
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
75.6
6.5
7
*
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
12.5
6.5
11
10
D04.8
ICD-10 Finland
Carcinoma in situ: Skin of other sites
+∞
6.3
6
*
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
9.8
6.3
12
14

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
60
246
6.55
14.12
4.6
2.4
—
—
—
0
0
33
91
5.43
12.05
1.8
1.4
—
—
—
0
0
58
358
3.18
5.37
10.8
6.0
2.00
1.68
e9/l
0.28
51
318
57
353
3.07
5.16
10.9
5.9
0.60
0.61
e9/l
0.12
50
306
57
354
3.06
5.11
10.9
5.9
0.04
0.04
e9/l
0.06
50
305
20
70
3.47
4.92
4.8
10.0
—
—
—
0
0
57
363
2.92
4.72
11.2
6.1
0.21
0.19
e9/l
0.17
49
317
57
364
2.91
4.68
6.4
4.6
34.88
34.33
g/l
0.34
52
338
42
230
2.72
4.66
3.3
2.3
—
—
—
0
0
39
213
2.60
4.26
2.6
2.3
3.36
2.99
mg/l
0.20
34
186
53
337
2.66
4.21
2.9
2.4
88.79
92.81
pmol/l
0.31
37
170
43
249
2.55
4.13
5.9
4.2
—
—
—
0
0
18
66
3.22
4.08
3.6
4.5
109.00
95.55
ng/l
0.18
13
57
42
244
2.50
3.96
10.2
5.7
—
—
—
0
0
12
30
4.51
3.78
1.1
1.3
—
—
—
0
0
74
600
3.70
3.65
34.7
21.2
34.88
24.24
mg/l
1.29
66
528
14
47
3.39
3.62
4.8
2.2
11.21
10.16
g/l
0.32
14
42
46
294
2.31
3.33
3.7
2.7
—
—
estimate
—
0
0
61
441
2.55
3.32
5.9
5.3
7.07
6.86
mmol/l
0.37
61
419
15
57
3.00
3.17
3.3
7.3
25.32
24.80
mmol/l
0.22
15
57
21
98
2.54
3.04
2.8
4.3
7.35
7.38
ph
0.80
12
62
63
475
2.47
2.92
6.8
6.1
—
338.63
—
0
16
14
55
2.87
2.79
3.7
9.5
93.41
93.23
%
0.05
14
55
16
68
2.69
2.77
1.1
1.2
—
—
—
0
0
74
624
3.15
2.76
39.4
25.9
3.98
4.02
mmol/l
0.57
74
610
74
624
3.15
2.76
38.3
25.8
139.12
139.50
mmol/l
0.54
74
610
66
518
2.48
2.63
12.3
8.2
82.10
79.13
u/l
0.39
61
491
16
70
2.60
2.61
2.6
2.4
271.88
271.98
ng/l
0.00
16
61
74
629
3.04
2.59
43.5
28.4
98.78
87.84
umol/l
0.65
74
619
67
537
2.43
2.42
5.2
4.9
1.18
1.22
mmol/l
0.21
61
462
17
80
2.42
2.39
1.5
1.4
—
—
—
0
0
6
13
4.89
2.31
1.2
1.1
—
—
—
0
0
28
165
2.07
2.31
5.4
4.3
508.09
364.62
ng/l
0.11
22
146
31
190
2.02
2.30
3.6
3.2
395.12
358.44
umol/l
1.25
25
158
69
566
2.48
2.26
5.9
5.7
3.98
4.25
mmol/l
1.64
63
498
69
567
2.46
2.23
7.7
8.4
39.98
41.41
mmol/mol
0.60
63
522
10
38
2.86
2.09
2.0
1.4
0.61
1.19
g/l
—
10
33
70
585
2.45
2.07
7.0
6.7
2.18
2.38
mmol/l
1.35
64
514
17
86
2.24
2.03
3.3
7.9
112.35
118.60
g/l
0.62
17
86
14
65
2.39
2.02
5.4
3.9
7.38
7.34
ph
—
8
40
23
132
2.04
2.01
4.3
3.7
1.40
2.18
e6/l
0.31
15
72
50
373
1.89
2.00
8.8
6.5
1.22
1.21
mmol/l
0.23
45
341
56
437
1.91
1.91
3.5
4.4
15.21
15.39
pmol/l
0.21
51
384
66
546
2.13
1.88
5.5
5.7
2.00
2.03
mu/l
0.08
60
477
19
104
2.08
1.87
3.3
7.0
7.44
7.41
ph
—
7
64
53
409
1.86
1.84
9.7
7.1
1.21
1.21
mmol/l
0.01
47
352
38
268
1.79
1.76
4.5
4.8
—
—
—
0
0
42
306
1.77
1.73
17.1
14.7
0.00
0.00
e9/l
0.32
33
256
11
49
2.44
1.72
2.0
2.1
1.19
1.39
g/l
0.56
11
42
35
242
1.79
1.72
3.5
3.1
25.50
73.70
mg/l
1.59
29
162
67
564
2.09
1.72
6.0
5.7
1.37
1.43
mmol/l
0.48
61
492
36
253
1.76
1.67
3.8
4.0
4.33
12.62
mg/mmol
1.79
28
162
9
38
2.54
1.51
2.7
2.6
—
—
—
0
0
19
114
1.87
1.44
1.7
1.7
—
—
—
0
0
9
41
2.34
1.42
3.8
8.7
14.60
15.04
%
—
9
41
37
272
1.66
1.40
4.2
4.0
—
—
—
0
0
21
133
1.78
1.35
3.8
5.9
103.62
104.31
mmol/l
0.22
21
133
48
385
1.61
1.24
22.0
17.2
1.39
1.32
inr
0.35
39
321
32
235
1.60
1.18
6.2
3.7
0.13
0.43
e6/l
1.93
26
176
20
132
1.68
1.11
3.8
3.1
19.28
21.21
%
0.34
20
124
20
134
1.65
1.05
3.7
3.1
2.23
2.20
g/l
0.10
20
122
11
62
1.90
1.00
2.7
2.6
6.00
6.10
ph
—
6
43
24
171
1.57
0.98
4.0
4.2
—
0.40
—
0
5
7
37
1.97
0.96
3.6
2.9
—
—
—
0
0
36
284
1.48
0.92
5.7
3.8
13.32
266.27
e6/l
0.58
29
219
14
88
1.71
0.91
4.1
3.9
2.80
9.40
ug/l
—
9
71
13
80
1.74
0.91
2.8
1.8
—
—
—
0
0
38
304
1.47
0.90
6.9
4.7
132.24
104.28
e6/l
0.12
29
228
21
148
1.57
0.90
1.1
1.3
—
—
—
0
0
15
97
1.67
0.89
1.1
1.3
—
—
—
0
0
6
32
1.94
0.83
6.8
4.1
340.38
29.37
mg/l
—
6
27
6
32
1.94
0.83
6.8
4.0
170.28
86.02
mg/l
—
6
27
20
142
1.54
0.83
8.7
5.3
—
—
—
0
0
33
263
1.43
0.78
7.7
4.5
7.39
7.39
ph
0.08
24
188
7
40
1.82
0.73
6.3
3.1
—
—
—
0
0
7
40
1.82
0.73
2.6
1.3
—
—
—
0
0
64
582
1.47
0.67
6.7
6.1
6.03
6.18
mmol/l
0.40
58
508
28
222
1.40
0.67
8.5
6.9
—
—
—
0
0
8
50
1.66
0.63
3.4
4.2
—
—
—
0
0
8
51
1.63
0.63
1.4
2.5
0.63
0.61
%
—
8
51
5
30
1.71
0.62
5.0
1.9
2.18
1.79
mg/l
—
5
24
0
20
0.00
0.61
0.0
1.2
—
—
—
0
0
8
53
1.56
0.60
3.0
1.7
—
—
—
0
0
66
609
1.45
0.58
28.3
18.7
—
—
—
0
0
6
40
1.54
0.53
1.2
1.3
—
—
—
0
0
10
67
1.56
0.52
4.5
2.5
—
—
—
0
0
43
376
1.31
0.52
4.6
4.8
0.00
0.00
estimate
—
6
93
5
31
1.65
0.44
1.4
1.2
—
—
—
0
0
8
57
1.45
0.44
1.9
1.6
—
—
—
0
0
15
189
0.75
0.40
4.4
4.4
—
—
—
0
0
17
136
1.32
0.37
2.2
1.9
28.61
29.34
s
0.29
17
129
42
378
1.23
0.36
4.9
4.8
0.00
16.92
estimate
—
6
96
6
46
1.33
0.34
1.3
1.2
—
—
—
0
0
7
51
1.41
0.32
1.4
2.5
1.33
1.15
%
—
7
51
15
121
1.29
0.31
5.3
3.2
1.79
1.77
%
0.03
15
106
42
383
1.20
0.30
4.8
4.9
0.00
0.00
estimate
—
6
84
9
71
1.30
0.27
1.2
1.3
—
—
—
0
0
9
72
1.28
0.27
1.9
1.8
—
—
—
0
0
49
459
1.17
0.23
5.5
4.9
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
2.7
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
7
60
1.18
0.18
1.4
1.8
—
—
—
0
0
10
85
1.20
0.13
1.5
3.1
0.23
1.25
e6/l
—
10
80
35
330
1.11
0.12
6.2
5.0
34.28
47.94
ng/l
0.83
28
278
24
224
1.10
0.09
1.7
2.0
1.25
1.18
mmol/l
0.25
19
185
6
53
1.14
0.09
2.8
2.5
13.97
13.11
nmol/l
—
6
45
33
314
1.09
0.09
3.9
4.3
6.20
6.29
ph
0.23
15
169
21
216
0.96
0.00
4.5
4.6
0.00
0.00
estimate
—
5
74
30
294
1.03
0.00
4.4
4.9
0.00
0.04
estimate
—
6
76
17
172
0.99
0.00
4.2
4.9
1.02
1.02
kg/l
—
9
115
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
15.50
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.8
—
57.20
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
9
0.00
-0.00
0.0
4.9
—
4.87
—
0
9
0
7
0.00
-0.00
0.0
6.0
—
33.17
—
0
7
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
4.37
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1.95
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
6.00
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
1.00
—
0
8
0
6
0.00
-0.00
0.0
1.8
—
-1.18
—
0
6

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_SKIN_EYELID – Carcinoma in situ of skin of eyelid, including canthus

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).