Merkel cell carcinoma of skin

C3_MERKEL_CELL_SKIN

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 C44
  • Cancer registry: Morphology ICD-O-3 8247
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

57

4. Check minimum number of events

None

57

5. Include endpoints

None

57

6. Filter based on genotype QC (FinnGen only)

51

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

First used in FinnGen datafreeze
DF9

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 51 26 25
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 74.68 73.90 75.49

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
52
Matched controls
520
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
32.8
28
*
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
97.1
26.8
28
6
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
18.9
17
*
C44.39
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face other or unspecified histology
+∞
17.7
16
*
8247/3-C44.3
ICD-O-3
Merkel cell carcinoma of skin of other and unspecified parts of face
+∞
16.5
15
*
R23.8
ICD-10 Finland
Other and unspecified skin changes
10.8
16.4
25
41
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
+∞
13.0
12
*
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
152.4
12.0
12
*
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
136.4
10.9
11
*
8247/3-C44.6
ICD-O-3
Merkel cell carcinoma of skin of upper limb and shoulder
+∞
10.8
10
*
JN4AD
NOMESCO Finland
Body CT examination
16.2
10.5
17
15
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
20.6
9.7
14
9
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
9.7
9
*
8247/3-C44.7
ICD-O-3
Merkel cell carcinoma of skin of lower limb and hip
+∞
9.7
9
*
C44.99
ICD-10 Finland
Unspecified localization of malignant tumor in skin other or unspecified histology
+∞
9.7
9
*
XX3DW
NOMESCO Finland
Time consuming IT work
15.4
8.7
14
12
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
+∞
8.6
8
*
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
+∞
8.6
8
*
ZZA00
NOMESCO Finland
Split skin graft
27.2
8.4
11
5
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
19.0
8.2
12
8
L57.0
ICD-10 Finland
Actinic keratosis
9.2
8.0
17
26
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
16.8
7.8
12
9
C44.69
ICD-10 Finland
Malignant tumor of the skin of the upper extremity including shoulder other or unspecified histology
+∞
7.5
7
*
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
+∞
7.5
7
*
C44.79
ICD-10 Finland
Malignant tumor of the skin of the lower extremity including hip or other unspecified histology
+∞
7.5
7
*
S18
ICPC
Laceration/cut
4.8
6.7
36
166
JN4BD
NOMESCO Finland
Extensive body CT
11.6
6.7
12
13
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
6.4
6
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
6.4
6
*
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
+∞
6.4
6
*
PJ5AQ
NOMESCO Finland
Sentinell lymphnode SPECT with low dose CT
+∞
6.4
6
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
6.4
6
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
6.4
6
*
130
Kela drug reimbursment
Malignant tumour
+∞
6.4
6
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
6.4
6
*
SPAT1153
SPAT
Removal of sutures
4.4
6.3
25
91

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
22
9
40.86
17.91
1.9
1.3
—
—
—
0
0
36
113
8.10
12.46
5.1
1.6
—
—
—
0
0
20
27
11.31
10.21
1.8
1.0
—
—
—
0
0
37
175
4.86
6.67
2.5
2.3
—
—
estimate
—
0
0
30
130
4.09
5.90
2.4
2.1
—
—
—
0
0
37
214
3.53
4.22
7.4
4.5
3.23
4.54
e9/l
5.14
30
174
10
20
5.92
3.92
1.1
1.2
—
—
—
0
0
22
111
2.70
2.92
3.4
3.4
72.27
82.58
%
0.99
22
111
13
50
3.13
2.78
1.7
2.0
—
—
—
0
0
35
228
2.64
2.70
9.2
5.6
1.22
1.21
mmol/l
0.20
28
202
27
164
2.34
2.32
2.7
3.3
33.67
34.62
e6/l
0.01
20
117
23
132
2.33
2.23
4.4
4.1
—
—
—
0
0
28
175
2.30
2.22
3.5
4.3
115.01
114.22
e6/l
0.00
20
123
16
78
2.52
2.20
2.3
2.5
2.30
2.19
g/l
0.33
16
72
31
206
2.25
2.09
5.3
4.2
0.04
0.04
e9/l
0.11
24
167
31
207
2.23
2.05
5.2
4.1
0.54
0.59
e9/l
0.69
24
167
24
145
2.22
2.02
2.4
3.1
0.70
0.30
e6/l
0.57
18
100
31
208
2.21
2.01
5.2
4.2
0.22
0.19
e9/l
0.31
26
170
6
16
4.09
2.00
7.8
2.9
—
—
—
0
0
28
186
2.09
1.81
4.6
3.7
6.39
6.23
ph
0.24
14
91
21
125
2.14
1.80
5.8
3.8
0.00
0.00
estimate
—
8
41
14
70
2.37
1.80
5.2
5.6
104.14
104.43
mmol/l
0.08
14
70
30
207
2.06
1.72
5.5
4.3
1.73
1.74
e9/l
0.05
24
169
32
228
2.05
1.67
5.4
3.8
0.00
0.00
estimate
—
8
50
27
181
2.02
1.66
14.6
9.6
0.00
0.00
e9/l
0.50
18
138
32
229
2.03
1.63
4.8
3.9
0.00
0.00
estimate
—
8
44
6
20
3.25
1.63
1.0
1.3
—
—
—
0
0
22
138
2.03
1.62
5.1
3.2
7.39
7.40
ph
0.45
17
93
16
90
2.12
1.55
1.3
1.3
—
—
—
0
0
32
232
1.99
1.54
32.3
16.2
1.60
1.36
inr
0.98
26
186
9
41
2.44
1.46
6.1
8.7
—
—
—
0
0
9
43
2.32
1.39
2.4
2.3
3.96
3.74
e9/l
—
9
36
31
229
1.88
1.35
5.5
3.8
0.00
0.00
estimate
—
7
49
14
80
2.03
1.29
3.1
3.1
0.71
0.75
ug/l
—
7
60
8
37
2.37
1.28
1.4
1.3
—
—
—
0
0
8
39
2.24
1.21
3.3
2.2
21.25
5.22
umol/l
—
8
32
12
67
2.03
1.16
4.0
3.3
—
—
—
0
0
7
31
2.45
1.15
5.3
8.2
95.37
93.95
%
—
7
31
7
32
2.37
1.13
4.1
6.3
25.46
24.37
mmol/l
—
7
32
7
33
2.29
1.10
5.3
7.7
0.84
0.59
%
—
7
33
7
33
2.29
1.10
5.3
7.8
1.29
1.05
%
—
7
33
11
61
2.02
1.08
1.6
1.8
—
—
—
0
0
14
85
1.89
1.08
2.5
2.5
13.81
12.26
umol/l
0.40
14
80
6
27
2.38
0.97
4.3
3.1
—
—
—
0
0
27
210
1.59
0.84
6.6
4.3
25.81
48.24
ng/l
1.47
21
160
9
52
1.88
0.82
5.0
5.7
122.56
121.23
g/l
—
9
52
6
33
1.92
0.82
5.3
2.7
—
—
—
0
0
35
292
1.61
0.79
5.4
4.3
—
—
—
0
0
5
24
2.19
0.77
2.2
2.1
—
0.00
estimate
—
0
8
44
391
1.81
0.77
28.5
15.1
—
—
—
0
0
5
27
1.94
0.70
2.2
2.1
1.18
0.96
%
—
5
27
17
123
1.57
0.69
4.8
4.7
—
—
—
0
0
5
28
1.87
0.68
2.2
2.0
0.74
0.51
%
—
5
28
5
28
1.87
0.68
1.4
1.3
—
—
—
0
0
18
133
1.54
0.67
6.1
4.1
—
—
—
0
0
21
163
1.48
0.62
6.8
4.0
0.00
0.00
estimate
—
7
38
8
55
1.54
0.46
1.4
1.6
—
—
—
0
0
5
31
1.68
0.44
1.2
1.4
—
—
—
0
0
5
31
1.68
0.44
2.6
2.7
—
—
—
0
0
8
58
1.45
0.44
1.1
1.3
—
—
—
0
0
20
164
1.36
0.41
4.0
3.4
—
—
—
0
0
5
35
1.47
0.40
1.0
1.3
—
—
—
0
0
14
114
1.31
0.29
4.9
3.8
0.00
0.00
estimate
—
8
36
5
39
1.31
0.23
1.8
1.7
232.80
369.29
nmol/l
—
5
34
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.2
—
1.12
—
0
11
0
10
0.00
0.21
0.0
2.0
—
108.20
—
0
10
0
10
0.00
0.21
0.0
2.0
—
1.21
—
0
10
0
10
0.00
0.21
0.0
2.0
—
4.06
—
0
10
0
14
0.00
0.20
0.0
1.6
—
131.00
—
0
9
7
62
1.15
0.18
4.9
3.5
1.04
1.41
mmol/l
—
7
53
19
172
1.16
0.14
4.1
4.0
1.42
9.46
mg/mmol
2.59
13
116
12
109
1.13
0.07
2.1
2.0
613.58
425.61
pmol/l
0.47
12
95
23
229
1.01
0.00
3.0
2.3
102.32
88.98
pmol/l
0.76
15
111
11
113
0.97
0.00
4.5
4.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
5.67
—
0
5
0
8
0.00
-0.00
0.0
3.9
—
0.75
—
0
8
0
9
0.00
-0.00
0.0
1.2
—
0.23
—
0
9
0
8
0.00
-0.00
0.0
2.1
—
9.88
—
0
8
0
9
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
1.15
—
0
9
0
5
0.00
-0.00
0.0
1.0
—
18.88
—
0
5
0
8
0.00
-0.00
0.0
2.1
—
105.50
—
0
8
0
8
0.00
-0.00
0.0
1.5
—
8.21
—
0
8
0
8
0.00
-0.00
0.0
4.3
—
15.13
—
0
8
0
8
0.00
-0.00
0.0
1.1
—
64.30
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
433.00
—
0
5

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_MERKEL_CELL_SKIN – Merkel cell carcinoma of skin

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).