Ependymoma

C3_EPENDYMOMA

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cancer registry: Topography ICD-O-3 ANY
  • Cancer registry: Morphology ICD-O-3 939[1-3]
  • Cancer registry: Behaviour codes 3

1 out of 7 registries used, show all original rules.

65

4. Check minimum number of events

None

65

5. Include endpoints

None

65

6. Filter based on genotype QC (FinnGen only)

59

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF9

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 59 34 25
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 48.64 47.40 50.32

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
62
Matched controls
620
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
9391/3-C72.0
ICD-O-3
Ependymoma, NOS, of spinal cord
+∞
36.0
31
*
H02AB02
ATC
dexamethasone; systemic
217.8
27.0
26
*
ABB10
NOMESCO Finland
Resection of lesion of spinal canal
+∞
21.0
19
*
ABB00
NOMESCO Finland
Excision of lesion of spinal canal
+∞
19.8
18
*
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
+∞
17.5
16
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
229.2
17.4
17
*
130
Kela drug reimbursment
Malignant tumour
+∞
16.4
15
*
C72.01
ICD-10 Finland
Malignant tumor of the spinal cord grade II glioma
+∞
15.2
14
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
15.7
15.2
26
27
C72.00
ICD-10 Finland
Malignant tumor of the spinal cord without histology
+∞
14.1
13
*
C72.09
ICD-10 Finland
Malignant tumor of the spinal cord other histology
+∞
12.9
12
*
C71.74
ICD-10 Finland
Malignant tumor of the brainstem ependyoma
+∞
11.8
11
*
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
73.0
11.1
12
*
WF002
NOMESCO Finland
Radical radiotherapy
131.3
10.8
11
*
D43.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Spinal cord
+∞
10.7
10
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
10.7
10
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
6.3
10.4
23
53
C71.51
ICD-10 Finland
Malignant tumor of cerebral ventricle ependymoma
+∞
9.6
9
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
9.6
9
*
D33.41
ICD-10 Finland
Myxopapillary epndymoma of the spinal cord (grade I)
+∞
9.6
9
*
D33.43
ICD-10 Finland
Spinal cord
+∞
9.6
9
*
9391/3-C71.7
ICD-O-3
Ependymoma, NOS, of brain stem
+∞
9.6
9
*
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
58.6
9.0
10
*
ZXE20
NOMESCO Finland
More than three and less than five hours
6.1
8.5
18
39
A04AA01
ATC
ondansetron; systemic, rectal
39.0
8.4
10
*
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
39.0
8.4
10
*
XX3DW
NOMESCO Finland
Time consuming IT work
16.0
8.3
13
10
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
51.8
7.9
9
*
AA1AD
NOMESCO Finland
CT of head and brain
4.6
7.8
27
89
A03FA01
ATC
metoclopramide; systemic, rectal
5.5
7.6
18
43
A04AA02
ATC
granisetron; systemic, transdermal
90.5
7.6
8
*
D33.40
ICD-10 Finland
Benign glioma of the spinal cord (grade I)
+∞
7.4
7
*
D33.4
ICD-10 Finland
Benign neoplasm: Spinal cord
+∞
7.4
7
*
D43.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, supratentorial
+∞
7.4
7
*
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
23.4
7.4
10
5
M03BX01
ATC
baclofen; systemic
34.5
7.4
9
*
WX408
NOMESCO Finland
General anesthesy, balanced
4.3
7.3
28
99
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
19.5
7.0
10
6
N03AX16
ATC
[U] pregabalin
4.4
7.0
24
78
YX8BD
NOMESCO Finland
Stereotactic extensive CT examination for dose design of radiotherapy
+∞
6.3
6
*
D43.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, infratentorial
+∞
6.3
6
*
ZX050
NOMESCO Finland
Stereotactic radiotherapy
+∞
6.3
6
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
4.1
6.1
22
73
XKD06
NOMESCO Finland
Physiologic investigation of micturition
17.2
6.1
9
6
R4110
NOMESCO Finland
Physiotherapy
3.8
6.1
27
104

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
25
43
9.07
15.42
6.3
7.2
7.39
7.41
ph
0.27
18
20
21
12
25.63
15.17
1.5
1.8
—
—
—
0
0
44
213
4.67
7.51
3.0
2.7
—
—
estimate
—
0
0
35
155
3.89
6.51
3.1
1.6
—
—
—
0
0
14
24
7.20
5.96
7.0
7.7
24.07
24.95
mmol/l
0.62
14
24
16
46
4.34
5.31
9.4
13.6
24.25
24.85
mmol/l
0.38
16
46
10
13
8.92
5.07
3.6
1.3
—
—
—
0
0
13
27
5.80
4.83
5.6
9.2
0.74
0.77
%
0.10
13
27
32
158
3.12
4.63
3.3
2.2
—
—
—
0
0
13
29
5.38
4.57
5.6
8.8
1.09
1.78
%
0.89
13
29
22
92
3.16
4.15
2.5
2.5
546.36
556.66
mosm/kgh2o
0.08
22
76
9
20
5.07
3.26
6.0
5.2
—
—
—
0
0
5
5
10.71
3.03
2.8
1.2
—
—
—
0
0
29
162
2.48
3.02
3.1
3.7
7.35
32.58
e6/l
1.24
24
116
22
108
2.61
2.99
2.5
3.0
1.96
7.76
e6/l
2.01
22
94
15
60
2.98
2.97
5.3
5.8
106.60
104.22
mmol/l
1.10
15
60
14
55
3.00
2.85
9.6
9.3
—
—
—
0
0
5
6
8.92
2.80
1.8
2.5
70.80
69.50
%
—
5
6
5
6
8.92
2.80
1.8
1.2
38.94
34.92
%
—
5
6
5
6
8.92
2.80
1.8
2.3
6.00
12.83
%
—
5
6
37
238
2.38
2.75
10.9
4.8
8.16
11.46
umol/l
2.64
37
222
21
105
2.51
2.72
4.7
3.1
—
—
—
0
0
6
11
5.90
2.61
3.5
6.7
3.83
3.85
mmol/l
—
6
11
5
7
7.64
2.59
1.8
2.6
27.40
23.14
%
—
5
7
5
8
6.67
2.41
1.8
3.1
19.80
12.25
%
—
5
8
11
41
3.04
2.35
1.1
1.1
—
—
—
0
0
6
15
4.31
2.09
4.8
5.5
18.83
22.99
nmol/l
—
6
15
29
185
2.07
2.03
9.7
10.4
1.12
1.19
inr
0.48
23
156
26
160
2.08
1.99
4.0
2.6
2.38
2.37
mmol/l
0.13
26
143
28
180
2.01
1.89
13.1
6.5
—
—
—
0
0
6
17
3.79
1.88
1.7
2.0
—
—
—
0
0
7
24
3.15
1.78
3.3
5.8
36.76
36.85
°c
—
7
24
42
501
0.50
1.63
5.7
5.4
2.77
2.76
mmol/l
0.05
42
472
29
198
1.87
1.58
3.8
4.3
17.13
56.73
e6/l
0.96
24
123
21
134
1.86
1.38
5.5
4.1
0.00
0.00
estimate
-0.00
11
45
34
254
1.75
1.31
23.9
8.3
0.00
0.00
e9/l
-0.00
28
191
21
136
1.82
1.31
5.0
2.8
—
—
—
0
0
14
79
2.00
1.30
4.7
1.6
2.47
2.44
mmol/l
0.48
14
62
22
146
1.79
1.27
1.2
1.5
—
—
—
0
0
15
225
0.56
1.11
3.9
2.8
—
—
—
0
0
12
68
1.95
1.10
8.3
5.8
7.37
7.38
ph
0.24
12
43
9
49
1.98
1.04
9.9
6.9
24.78
23.62
mmol/l
—
9
49
7
35
2.12
1.04
4.4
4.7
—
0.00
—
0
9
33
256
1.62
1.03
16.6
6.1
55.35
53.44
%
0.45
33
246
11
62
1.94
1.02
1.8
1.8
—
—
—
0
0
8
42
2.04
0.93
9.6
15.9
7.42
7.42
ph
—
8
35
19
134
1.60
0.85
4.1
3.8
7.40
7.40
ph
0.20
12
89
17
231
0.64
0.79
4.5
3.8
6.06
6.15
ph
—
8
127
5
23
2.27
0.78
10.0
1.6
—
—
—
0
0
35
288
1.49
0.77
16.2
5.8
0.52
0.53
e9/l
0.04
30
241
15
208
0.63
0.76
2.4
2.0
1.41
1.26
mmol/l
0.24
15
178
35
291
1.47
0.71
16.2
5.7
0.03
0.04
e9/l
0.88
29
242
9
138
0.59
0.71
3.9
3.3
—
—
—
0
0
35
292
1.46
0.69
16.3
5.8
1.77
2.08
e9/l
1.24
30
254
8
50
1.69
0.64
1.3
1.8
—
—
—
0
0
0
19
0.00
0.61
0.0
1.1
—
—
—
0
0
0
22
0.00
0.60
0.0
1.2
—
—
—
0
0
6
35
1.79
0.60
1.5
1.1
—
—
—
0
0
6
35
1.79
0.60
10.5
16.2
—
—
—
0
0
0
23
0.00
0.59
0.0
1.3
—
9.58
—
0
5
0
23
0.00
0.59
0.0
1.2
—
251.67
—
0
9
35
299
1.39
0.57
17.2
5.8
0.16
0.21
e9/l
1.47
29
259
9
64
1.47
0.54
2.4
5.0
1.36
1.65
%
—
9
55
6
90
0.63
0.46
1.2
1.6
—
—
—
0
0
5
33
1.56
0.42
5.4
4.5
—
0.36
—
0
11
5
33
1.56
0.42
5.4
5.0
—
0.25
—
0
8
5
33
1.56
0.42
5.4
5.5
7.32
7.37
ph
—
5
24
0
15
0.00
0.42
0.0
1.7
—
—
—
0
0
0
15
0.00
0.42
0.0
1.5
—
—
—
0
0
0
17
0.00
0.41
0.0
1.9
—
—
—
0
0
9
66
1.42
0.41
2.1
1.7
—
—
—
0
0
0
18
0.00
0.40
0.0
1.0
—
—
—
0
0
10
74
1.42
0.35
1.5
3.3
20.90
24.47
%
—
10
68
10
74
1.42
0.35
1.0
1.2
—
—
—
0
0
25
283
0.80
0.30
6.2
3.9
0.00
0.00
estimate
-0.00
11
47
20
173
1.23
0.25
3.0
3.5
14.82
47.22
ng/l
0.93
11
108
5
37
1.38
0.24
14.4
3.1
—
—
—
0
0
5
38
1.34
0.24
1.4
1.5
—
—
—
0
0
10
123
0.78
0.23
3.4
4.0
1.02
1.02
kg/l
—
5
74
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
9.66
—
0
6
0
11
0.00
0.21
0.0
1.0
—
17.71
—
0
5
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
1.2
—
2.95
—
0
10
0
10
0.00
0.21
0.0
1.2
—
0.35
—
0
10
0
10
0.00
0.21
0.0
1.2
—
6.78
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
6
49
1.25
0.21
1.3
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
5.1
—
28.94
—
0
9
8
69
1.18
0.17
1.4
1.6
—
—
—
0
0
22
200
1.16
0.15
2.3
2.0
86.77
101.17
pmol/l
0.90
13
92
15
167
0.87
0.12
4.1
1.5
1.82
2.37
g/l
—
9
91
26
278
0.89
0.12
6.0
3.9
0.00
0.00
estimate
-0.00
11
48
46
476
0.87
0.12
5.6
6.2
37.25
38.63
mmol/mol
0.55
46
452
12
106
1.16
0.10
3.5
4.0
0.94
2.47
ug/l
2.38
12
94
26
276
0.90
0.10
5.6
3.9
0.00
0.00
estimate
-0.00
12
48
19
204
0.90
0.08
6.4
3.7
0.00
0.03
estimate
—
9
40
7
66
1.07
0.08
1.6
1.7
—
—
—
0
0
7
79
0.87
0.07
1.3
1.2
—
—
—
0
0
9
86
1.05
0.07
1.9
2.0
428.78
445.91
pmol/l
—
9
74
8
94
0.83
0.07
1.4
1.7
—
—
—
0
0
19
183
1.06
0.01
18.7
4.4
—
—
—
0
0
43
429
1.01
0.00
5.0
4.5
14.33
14.67
pmol/l
0.37
43
396
18
176
1.03
0.00
1.1
1.6
0.50
0.74
u/ml
—
6
41
12
122
0.98
0.00
1.4
2.0
—
—
—
0
0
12
122
0.98
0.00
8.3
4.3
—
—
—
0
0
15
152
0.98
0.00
7.4
3.6
0.00
0.00
estimate
—
9
40
6
61
0.98
0.00
2.5
2.5
4.31
4.06
e9/l
—
6
52
0
7
0.00
-0.00
0.0
2.6
—
2.03
—
0
7
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
7.24
—
0
5
0
7
0.00
-0.00
0.0
4.1
—
4.83
—
0
7
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.1
—
8.50
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
6.3
—
1.73
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
8.0
—
0.60
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.8
—
-1.10
—
0
5
0
8
0.00
-0.00
0.0
3.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
2.07
—
0
8
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
13.28
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
312.67
—
0
6
0
5
0.00
-0.00
0.0
28.0
—
168.60
—
0
5
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
98.83
—
0
6

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_EPENDYMOMA – Ependymoma

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).