This is a non-core endpoint: only basic statistics are computed.
Bradycardia, unspecified, drug-induced
BRADY_UNSPE
No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
557745 |
1. Apply sex-specific ruleNone |
557745 |
2. Check conditionsNone |
557745 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
114 |
4. Check minimum number of eventsNone |
114 |
5. Include endpointsNone |
114 |
6. Filter based on genotype QC (FinnGen only) |
98 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Bradycardia, unspecified, drug-induced
based on the number of shared cases.
Similar with more cases:
- Abnormalities of heart beat
- Symptoms and signs involving the circulatory and respiratory systems
- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
- Any operation in hilmo
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 98 | 45 | 53 |
| Unadjusted period prevalence (%) | 0.02 | 0.02 | 0.02 |
| Median age at first event (years) | 62.80 | 60.22 | 64.99 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 101
- Matched controls
- 1010
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R00.1
ICD-10 Finland
Bradycardia, unspecified
+∞
126.3
101
16
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
9.3
19.3
27
38
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
6.8
14.9
28
54
I49.5
ICD-10 Finland
Sick sinus syndrome
7.5
13.1
21
34
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
15.4
10.6
17
13
73
HP
Initial pacemaker installation
61.0
9.9
11
*
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
9.3
9.7
20
26
XF404
NOMESCO Finland
Ambulatory ECG
5.1
8.9
21
49
XFP02, ,
NOMESCO Finland
+∞
6.3
6
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
23
126
2.07
2.21
4.0
3.1
2.43
1.95
e6/l
0.15
15
58
26
155
1.91
1.98
2.1
2.6
12.42
12.26
umol/l
0.04
26
146
38
260
1.74
1.85
3.6
3.9
2.39
2.34
mmol/l
1.72
32
240
23
138
1.86
1.70
4.3
3.0
1.34
1.09
e6/l
0.11
18
71
5
14
3.70
1.63
1.4
1.1
—
—
—
0
0
0
38
0.00
1.37
0.0
1.8
—
—
—
0
0
5
17
3.04
1.37
1.8
3.2
6.90
14.31
pmol/l
—
5
17
0
41
0.00
1.34
0.0
1.9
—
—
—
0
0
5
19
2.71
1.23
1.2
1.4
—
—
—
0
0
37
281
1.50
1.10
4.2
3.6
—
—
—
0
0
41
322
1.46
1.02
2.4
2.7
74.09
78.21
nmol/l
0.44
35
285
31
231
1.49
1.00
4.6
3.3
0.28
0.65
e6/l
1.09
24
172
0
30
0.00
0.99
0.0
1.4
—
—
—
0
0
0
31
0.00
0.98
0.0
1.4
—
—
—
0
0
0
24
0.00
0.80
0.0
1.5
—
—
—
0
0
0
27
0.00
0.78
0.0
1.5
—
—
—
0
0
5
23
2.23
0.77
1.0
1.7
—
—
—
0
0
17
120
1.50
0.70
4.6
7.0
104.18
104.02
mmol/l
0.03
17
120
41
341
1.34
0.69
2.4
2.5
86.34
91.63
pmol/l
0.27
25
184
41
344
1.32
0.64
2.6
2.8
—
—
—
0
0
0
20
0.00
0.61
0.0
1.4
—
—
—
0
0
0
21
0.00
0.61
0.0
1.5
—
—
—
0
0
18
236
0.71
0.60
3.6
4.0
7.16
8.80
mg/mmol
0.17
11
157
57
506
1.29
0.57
3.7
4.9
15.17
14.49
mm/h
0.09
52
464
6
37
1.66
0.56
1.3
2.8
0.48
0.54
g/l
—
6
32
38
322
1.29
0.54
2.6
2.6
—
—
estimate
—
0
0
46
402
1.26
0.51
5.1
7.4
1.21
1.21
mmol/l
0.38
40
345
22
178
1.30
0.43
2.4
2.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
54
489
1.22
0.41
4.9
4.2
14.96
15.04
pmol/l
0.08
46
426
65
600
1.23
0.41
5.8
5.4
2.04
2.00
mu/l
0.08
58
524
0
17
0.00
0.41
0.0
4.1
—
22.86
—
0
7
0
17
0.00
0.41
0.0
1.5
—
—
—
0
0
0
17
0.00
0.41
0.0
1.5
—
—
—
0
0
0
18
0.00
0.40
0.0
1.3
—
—
—
0
0
5
35
1.45
0.40
1.0
1.1
—
—
—
0
0
32
275
1.24
0.40
5.5
4.7
0.00
0.03
estimate
—
5
69
11
82
1.38
0.36
1.5
2.9
64.17
66.07
g/l
0.41
11
77
13
101
1.33
0.33
1.3
1.3
14.00
45.69
iu/ml
—
5
34
41
369
1.19
0.31
5.2
4.6
0.00
0.00
estimate
—
6
84
7
55
1.29
0.30
1.6
2.1
—
—
—
0
0
18
149
1.25
0.30
3.4
5.3
1.02
1.02
kg/l
0.03
13
98
8
65
1.25
0.28
1.3
1.3
—
—
—
0
0
41
373
1.17
0.27
5.2
4.6
0.00
18.45
estimate
—
6
88
6
82
0.71
0.25
1.5
1.8
406.33
389.24
nmol/l
—
6
75
12
146
0.80
0.24
1.9
2.8
0.80
0.81
mmol/l
0.11
12
135
14
116
1.24
0.23
1.5
2.1
—
—
—
0
0
10
124
0.79
0.23
1.8
5.7
0.94
1.03
mmol/l
—
10
114
23
202
1.18
0.23
3.5
4.6
27.90
23.51
%
—
10
106
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
10
0.00
0.21
0.0
3.5
—
89.47
—
0
10
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
58
548
1.14
0.21
8.6
8.7
75.04
82.48
u/l
0.82
51
517
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
243.30
—
0
12
41
379
1.14
0.21
5.2
4.7
0.00
0.00
estimate
—
6
81
43
402
1.12
0.18
6.7
9.9
4.50
4.47
e9/l
0.02
35
346
5
69
0.71
0.17
1.4
1.4
—
—
—
0
0
17
152
1.14
0.13
2.9
3.1
1.26
0.93
ug/l
—
9
110
14
124
1.15
0.12
1.5
2.0
—
—
—
0
0
23
212
1.11
0.11
3.6
3.4
32.57
31.77
u/l
0.07
23
198
64
620
1.09
0.11
4.7
5.5
5.91
6.05
mmol/l
0.47
56
553
68
698
0.92
0.10
37.6
30.6
38.63
39.17
%
0.30
68
685
68
698
0.92
0.10
37.3
30.3
129.06
130.87
g/l
0.46
68
685
20
212
0.93
0.06
3.0
4.6
0.00
0.00
estimate
—
5
75
26
252
1.04
0.02
1.9
2.0
1.36
1.33
mmol/l
0.07
21
207
68
688
0.96
0.02
33.6
27.0
80.90
85.26
umol/l
0.69
68
674
62
628
0.97
0.02
6.1
6.0
2.64
2.49
mmol/l
0.55
57
562
68
678
1.01
0.00
31.0
24.8
3.94
4.01
mmol/l
1.53
68
660
68
679
1.00
0.00
31.0
24.7
139.87
139.51
mmol/l
0.49
68
663
35
346
1.02
0.00
6.4
4.8
26.20
48.67
ng/l
1.92
25
275
10
95
1.06
0.00
3.5
3.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
14.22
—
0
9
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
13.63
—
0
8
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
50
1.00
-0.00
1.6
1.9
10.90
12.04
nmol/l
—
5
44
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
42.42
—
0
5
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
44.33
—
0
6
17
170
1.00
-0.00
1.4
2.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
108.29
—
0
7
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
20.00
—
0
5
0
5
0.00
-0.00
0.0
3.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
69.95
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
807.20
—
0
5
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
7
72
0.97
-0.00
1.3
1.6
—
—
—
0
0
5
56
0.89
-0.00
4.2
6.5
23.20
24.47
mmol/l
—
5
56
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: BRADY_UNSPE – Bradycardia, unspecified, drug-induced
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).