Relapsing fevers, including avohilmo

AB1_RELAP_FEVER_WIDE

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Primary healthcare outpatient: ICD-10 — A68 Hospital discharge: ICD-10 — A68 Hospital discharge: ICD-9 — 08[7] Hospital discharge: ICD-8 — 08[8] Cause of death: ICD-10 — A68 Cause of death: ICD-9 — 08[7] Cause of death: ICD-8 — 08[8] 3 out of 7 registries used, show all original rules.	103
4. Check minimum number of events None	103
5. Include endpoints None	103
6. Filter based on genotype QC (FinnGen only)	92

Control definitions (FinnGen only)

Control exclude: AB1_OTHER_SPIROCHAETAL

Extra metadata

Level in the ICD hierarchy: 3
First used in FinnGen datafreeze: DF13

NAME	AB1_RELAP_FEVER_WIDE
CONTROL_EXCLUDE	AB1_OTHER_SPIROCHAETAL
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD	A68
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	A68
HD_ICD_9	08[7]
HD_ICD_8	08[8]
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	A68
COD_ICD_9	08[7]
COD_ICD_8	08[8]
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Relapsing fevers, including avohilmo based on the number of shared cases.

Similar with more cases:

Similar with less cases:

Relapsing fevers

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	92	51	41
Unadjusted period prevalence (%)	0.02	0.02	0.02
Median age at first event (years)	32.55	23.95	43.23

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
95: Matched controls
950

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

A68.9

ICD-10 Finland

Relapsing fever, unspecified

+∞

66.7

0879X

ICD-9 Finland

Relapsing fever, unspecified

+∞

24.0

R50.9

ICD-10 Finland

Fever, unspecified

8.0

23.4

116

EMB10

NOMESCO Finland

Tonsillectomy

7.4

8.4

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

3.1

6.1

145

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3028026) IgM [Mass/volume] in Serum or Plasma

3.96

5.63

1.3

1.4

1.15

1.22

g/l

0.16

(3005322) IgE [Units/volume] in Serum or Plasma

3.10

4.12

1.2

73.84

448.34

u/ml

0.55

(3019539) Treponema pallidum Ab [Titer] in Serum by Hemagglutination

7.45

3.42

1.4

1.5

—

(3029634) Reagin Ab [Titer] in Serum by VDRL

7.45

3.42

1.7

1.6

—

(42870588) Differential panel, method unspecified - Blood

269

2.18

3.39

9.6

5.6

—

(3049804) Myeloperoxidase IgG Ab [Units/volume] in Serum

6.20

3.08

1.1

1.5

—

(4062490) Immunoglobulin typing, IgG

7.02

2.91

1.0

1.1

—

(3027953) Aldolase [Enzymatic activity/volume] in Serum or Plasma

8.70

2.78

1.0

1.8

6.90

11.78

u/l

—

(3023368) Bacteria identified in Blood by Culture

172

2.09

2.62

5.6

4.4

—

(3003327) Ova and parasites identified in Stool by Light microscopy

3.23

2.59

1.0

1.8

—

(40760892) CBC W Ordered Manual Differential panel - Blood

184

2.02

2.45

3.8

5.3

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

218

1.96

2.41

2.6

3.9

18.96

32.34

ng/l

0.66

133

(3041942) Cyclic citrullinated peptide Ab [Units/volume] in Serum

130

2.13

2.41

1.3

1.4

0.90

8.86

u/ml

—

(3003191) Choriogonadotropin [Presence] in Serum or Plasma

0.00

2.34

0.0

1.7

—

(3012110) Lysozyme [Mass/volume] in Serum or Plasma

5.79

2.24

1.0

1.9

17.20

15.07

mg/l

—

(3019832) Treponema pallidum Ab [Presence] in Serum

144

2.00

2.12

2.1

1.7

—

(3014162) Mycobacterium tuberculosis DNA [Presence] in Specimen by NAA with probe detection

3.69

2.10

1.6

2.3

—

(3009340) Metanephrine [Moles/volume] in Serum or Plasma

5.21

2.09

1.4

1.8

—

(3021614) Rheumatoid factor [Units/volume] in Serum or Plasma

145

1.98

2.08

1.4

19.72

30.27

iu/ml

—

(3001334) Neutrophil cytoplasmic Ab [Units/volume] in Serum

3.26

2.06

1.1

1.3

—

(40768797) Stomach Pathology biopsy report

2.22

2.06

1.2

—

(3035350) Ketones [Presence] in Urine by Test strip

402

1.80

2.05

5.9

3.7

99.85

0.00

estimate

0.47

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

2.90

1.99

1.3

1.2

—

(3021601) Nitrite [Presence] in Urine by Test strip

395

1.77

1.98

5.9

3.6

0.00

estimate

-0.00

(3041096) Erythrocytes [Presence] in Urine by Automated

223

1.82

1.95

5.1

2.9

0.00

0.02

estimate

0.49

(3051714) Fibrin D-dimer FEU [Mass/volume] in Platelet poor plasma

157

1.90

1.92

2.4

2.0

1.24

1.29

mg/l

0.03

130

(3037467) Urinalysis macro (dipstick) panel - Urine

499

1.78

1.86

6.9

4.1

—

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

252

1.77

1.86

4.9

3.4

—

(3015736) pH of Urine

325

1.73

1.84

5.0

3.2

6.28

6.30

0.06

185

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

307

1.73

1.83

6.0

3.3

0.00

0.02

estimate

0.49

(3009261) Glucose [Presence] in Urine by Test strip

403

1.71

1.78

5.9

3.7

0.00

estimate

-0.00

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

578

1.80

1.72

7.3

4.3

12.44

9.26

mm/h

0.99

545

(3042936) Bacteria identified in Isolate by Culture

2.01

1.64

2.7

2.6

—

(3009508) Creatinine [Moles/volume] in Urine

251

1.70

1.63

4.6

3.0

7.77

8.52

mmol/l

0.41

229

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

2.82

1.61

1.6

1.7

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

126

1.86

1.57

2.7

1.9

—

(46235759) Influenza virus B RNA [Presence] in Nasopharynx by NAA with probe detection

2.62

1.48

1.3

2.4

—

(3006999) Ribonucleoprotein extractable nuclear Ab [Units/volume] in Serum

2.62

1.48

1.0

1.1

—

18.74

—

(3027945) Reticulocytes/Erythrocytes in Blood

2.05

1.48

4.3

3.3

1.33

1.68

1.13

(3005136) Cladosporium herbarum IgE Ab [Units/volume] in Serum

3.24

1.45

1.0

—

1.56

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.38

1.44

1.2

1.7

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

624

1.73

1.43

4.6

3.8

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

2.52

1.42

1.1

—

5.76

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

251

1.62

1.40

2.0

1.8

—

(3018095) Leukocytes [#/volume] in Urine

282

1.58

1.30

4.3

3.8

36.88

31.24

e6/l

0.09

195

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

2.49

1.26

1.3

1.9

—

(3036086) Jo-1 extractable nuclear Ab [Units/volume] in Serum by Immunoassay

2.49

1.26

1.0

1.1

—

(3024403) Complement+Immunoglobulin [Units/volume] in Red Blood Cells

2.72

1.23

1.2

2.1

—

(40758558) Short blood count panel - Blood

249

1.57

1.22

7.1

5.8

—

(3023420) DNA double strand Ab [Units/volume] in Serum

2.15

1.18

1.1

1.6

—

5.17

—

(3017895) Helicobacter pylori Ab [Units/volume] in Serum

0.00

1.16

0.0

1.6

—

5.59

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

2.58

1.16

1.4

—

(3016771) Amylase [Enzymatic activity/volume] in Serum or Plasma

226

1.55

1.13

6.0

2.7

54.94

53.46

u/l

0.11

215

(46235355) HIV 1 and 2 tests - Meaningful Use set

235

1.55

1.13

2.5

2.0

—

(3029879) Epithelial cells.squamous [#/volume] in Urine by Automated count

107

1.72

1.09

2.8

3.62

4.44

e6/l

—

(40761535) Cells panel - Urine sediment

1.94

1.08

3.1

3.0

—

(3025941) Bacteria identified in Stool by Culture

2.05

1.07

1.3

1.1

—

(3012516) Albumin [Mass/volume] in Urine

193

1.56

1.06

5.4

3.3

42.02

60.34

mg/l

0.25

137

(3019150) Specific gravity of Urine by Refractometry

202

1.55

1.06

6.2

3.5

1.02

kg/l

0.00

129

(3004588) Protein electrophoresis panel - Serum or Plasma

2.14

1.05

1.4

2.6

—

(3008898) HLA-B27 [Presence]

1.92

1.02

1.0

1.1

—

(3020682) Albumin/Creatinine [Ratio] in Urine

195

1.54

1.02

7.3

3.8

5.43

9.03

mg/mmol

0.41

135

(3020460) C reactive protein [Mass/volume] in Serum or Plasma

770

1.79

0.99

21.2

14.0

21.60

22.29

mg/l

0.09

613

(3018418) pH of Serum or Plasma

214

1.51

0.99

5.2

3.9

7.40

0.79

147

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

1.84

0.98

1.8

1.4

—

(3004529) Oxygen [Partial pressure] adjusted to patient's actual temperature in Venous blood

2.30

0.95

3.3

2.9

40.90

53.71

—

(3044254) Respiratory syncytial virus RNA [Presence] in Specimen by NAA with probe detection

2.30

0.95

1.3

2.3

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

2.30

0.95

1.3

1.9

—

(3026008) Bacteria identified in Urine by Culture

200

1.49

0.90

3.6

2.7

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

284

1.43

0.87

2.4

2.0

100.11

91.56

pmol/l

0.59

161

(3025839) Triglyceride [Moles/volume] in Serum or Plasma

316

0.68

0.85

2.4

1.9

1.15

1.33

mmol/l

0.70

282

(3002582) Erythrocytes [#/volume] in Urine

242

1.42

0.79

4.1

3.2

10.88

313.19

e6/l

0.61

190

(3021337) Troponin I.cardiac [Mass/volume] in Serum or Plasma

126

1.53

0.77

8.8

3.6

16.00

383.31

ng/l

1.42

(1002102) Choriogonadotropin.intact+Beta subunit [Mass/volume] in Serum or Plasma

2.24

0.77

1.6

86.04

43.18

ug/l

—

(3029937) Albumin [Presence] in Urine by Test strip

225

1.42

0.76

7.1

3.6

0.00

0.01

estimate

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

2.14

0.75

1.4

1.0

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

128

1.50

0.72

3.2

4.1

16.27

22.66

—

(3024354) Oxygen [Partial pressure] in Venous blood

1.67

0.72

6.0

4.2

3.81

4.75

kpa

2.00

(3050380) Cytology report of Cervical or vaginal smear or scraping Cyto stain

1.97

0.71

1.4

1.3

—

(3002482) Mycoplasma pneumoniae DNA [Presence] in Specimen by NAA with probe detection

1.97

0.71

2.2

1.4

—

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

1.97

0.71

4.4

3.4

3.04

3.25

g/l

—

(3000494) Fungus identified in Specimen by Culture

1.57

0.67

1.8

1.7

—

(3013512) EKG study

195

1.38

0.63

3.0

3.4

—

(40771025) 25-Hydroxyvitamin D3+25-Hydroxyvitamin D2 [Moles/volume] in Serum or Plasma

358

1.31

0.59

3.1

2.7

84.00

70.73

nmol/l

1.91

332

(3019060) Gas panel - Arterial blood

1.76

0.59

2.7

17.1

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.50

0.56

3.5

1.7

—

(40761536) Microorganisms panel - Urine sediment

1.47

0.54

6.3

3.0

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

1.49

0.52

7.2

9.0

103.42

105.00

mmol/l

0.90

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

146

1.38

0.52

1.8

1.7

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.46

0.51

3.4

1.6

—

(3030467) Casts [#/volume] in Urine by Automated count

203

1.31

0.49

3.7

3.0

0.01

0.36

e6/l

3.26

152

(3000850) Epithelial cells [#/volume] in Urine

166

1.34

0.49

3.7

2.9

4.05

6.13

e6/l

0.72

151

(3030306) Epithelial cells.non-squamous [#/volume] in Urine by Automated count

121

1.39

0.48

3.1

2.7

0.34

0.88

e6/l

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.43

0.46

6.8

1.7

—

(3000991) Gas panel - Venous blood

1.50

0.46

11.1

13.5

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

1.65

0.44

4.4

2.4

171.62

174.03

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.59

0.43

1.6

3.7

0.76

0.64

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

1.54

0.42

1.6

3.6

1.42

1.65

—

(3020321) Streptococcus agalactiae [Presence] in Vaginal fluid by Organism specific culture

1.54

0.42

1.2

1.7

—

(3042206) Streptococcus agalactiae Ag [Presence] in Vaginal fluid

0.00

0.41

0.0

1.2

—

(3038177) Helicobacter pylori Ab [Presence] in Serum

0.00

0.41

0.0

1.1

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.41

0.0

1.5

—

(3025130) Human papilloma virus identified in Specimen

0.00

0.39

0.0

2.2

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.36

0.39

6.4

9.6

25.91

24.49

mmol/l

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

1.41

0.39

4.2

3.3

84.40

96.47

—

(40761511) CBC panel - Blood by Automated count

794

1.36

0.38

17.4

11.2

—

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

615

1.24

0.38

4.7

3.9

14.39

14.56

pmol/l

0.24

571

(3003458) Phosphate [Moles/volume] in Serum or Plasma

117

1.33

0.38

7.7

7.6

1.05

1.14

mmol/l

0.55

109

(3003396) Base excess in Arterial blood by calculation

1.32

0.38

7.7

18.9

1.30

0.86

mmol/l

—

(3001019) Free T4 and TSH panel - Serum or Plasma

1.49

0.37

1.0

1.7

—

(3044640) Blood type and Crossmatch panel - Blood

230

1.24

0.36

2.2

2.4

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

184

1.25

0.34

1.8

1.6

—

(3028626) Oxygen [Partial pressure] in Capillary blood

1.36

0.34

2.2

6.6

8.78

9.04

kpa

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

166

1.26

0.33

2.2

2.6

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

204

1.24

0.33

2.7

2.4

—

(4035726) Immunohistochemistry procedure

1.32

0.31

2.3

1.4

—

(3022313) Gas panel - Capillary blood

1.32

0.31

5.0

6.5

—

(3011288) Drugs identified in Urine by Screen method Nominal

1.32

0.29

1.0

1.6

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

191

1.20

0.25

2.6

2.1

—

(4024509) Urine culture

1.37

0.24

1.6

2.1

—

(1002224) Polysomnography panel

1.30

0.23

1.0

—

(3007164) IgA [Mass/volume] in Serum or Plasma

231

1.17

0.23

1.5

1.4

2.39

2.02

g/l

0.53

135

(3028707) Methadone [Presence] in Urine by Screen method

1.23

0.22

1.2

1.6

—

(3019050) Tissue transglutaminase IgA Ab [Units/volume] in Serum

261

1.16

0.22

1.6

1.4

2.10

2.13

u/ml

—

(3008832) Norclozapine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

13.5

—

934.36

—

(3024666) Lithium [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

9.4

—

0.57

—

(3020191) Ethanol [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

1.1

—

1.67

—

(3000081) cloZAPine [Moles/volume] in Serum or Plasma

0.00

0.21

0.0

19.0

—

1888.08

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

0.21

0.0

1.1

—

(3000855) Microscopic observation [Identifier] in Vaginal fluid by Gram stain

0.00

0.21

0.0

1.5

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

341

1.14

0.20

3.3

2.9

—

estimate

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

100

1.23

0.19

3.3

2.1

—

(4010399) Spirometry for bronchospasm with prolonged evaluation after bronchodilator

1.20

0.18

1.6

1.4

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.18

0.18

9.4

4.8

25.44

23.56

mmol/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.14

0.18

4.0

3.8

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

1.14

0.18

1.9

1.5

—

(3016879) Cocaine [Presence] in Urine

0.76

0.16

1.2

1.5

—

(3027944) Amphetamines [Presence] in Urine

0.75

0.16

1.2

1.5

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

121

1.18

0.16

3.0

2.2

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

121

1.18

0.16

1.6

1.5

—

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.14

0.15

8.4

2.0

30.56

31.73

u/l

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

141

1.16

0.15

1.5

1.4

—

(3003031) Transferrin.carbohydrate deficient.disialo/Transferrin.total in Serum or Plasma

128

0.84

0.14

1.5

1.7

1.67

1.38

0.66

113

(3002256) Pathology report gross observation

1.18

0.11

1.4

1.2

—

(3050129) First trimester maternal screen panel - Serum or Plasma

1.17

0.10

1.2

1.3

—

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

1.17

0.10

1.2

1.1

—

(3023511) Choriogonadotropin [Units/volume] in Urine

1.17

0.10

1.2

1.3

—

(21494755) Public health laboratory ask at order entry panel

1.15

0.09

1.7

1.3

—

(36660697) Celiac disease serology panel - Serum

107

1.14

0.09

1.8

1.1

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

686

0.92

0.09

16.1

12.5

86.85

91.14

ml/min/173m2

0.90

608

(3021589) Normoblasts [#/volume] in Blood

384

1.07

0.08

12.5

9.5

0.00

e9/l

0.80

299

(3022145) Colonoscopy Study observation

1.10

0.08

1.1

1.3

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.03

0.07

2.1

2.0

—

(3000492) Spirometry study

1.09

0.07

1.6

1.5

—

(3003694) ABO and Rh group [Type] in Blood

232

0.93

0.05

2.0

1.6

—

(1761868) Lipid panel - Serum or Plasma

303

1.03

0.01

2.9

2.6

—

(3002385) Erythrocyte [DistWidth] in Red Blood Cells

686

0.97

0.00

22.0

16.7

13.33

13.37

0.12

676

(40768804) Tissue Pathology biopsy report

286

1.02

0.00

2.3

1.9

—

(3012441) Differential panel - Pleural fluid

0.00

0.0

1.3

—

(3022493) Free Hemoglobin [Mass/volume] in Plasma

0.00

0.0

1.4

—

91.00

—

(3006442) Creatine [Moles/volume] in Serum or Plasma

0.00

0.0

2.1

—

61.63

—

(40763082) Lactate dehydrogenase [Enzymatic activity/volume] in Pleural fluid by Lactate to pyruvate reaction

0.00

0.0

1.3

—

217.63

—

(40759040) C peptide [Moles/volume] in Serum or Plasma --post meal

0.00

0.0

1.0

—

1.22

—

(3028531) Enolase.neuron specific [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

16.58

—

(3005570) Glucose [Moles/volume] in Urine

0.00

0.0

1.8

—

(4198724) Urine methamphetamine measurement

0.00

0.0

2.6

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

6.6

—

(3036428) Adenosine deaminase [Enzymatic activity/volume] in Pleural fluid

0.00

0.0

1.2

—

9.40

—

(3011897) Casein IgE Ab [Units/volume] in Serum

0.00

0.0

1.0

—

0.09

—

(3013201) Beta-2-Microglobulin [Mass/volume] in Serum or Plasma

0.00

0.0

1.8

—

3.62

—

(3013727) Leukocytes other/Leukocytes in Blood

0.00

0.0

6.2

—

56.50

—

(3021236) Streptolysin O Ab [Units/volume] in Serum or Plasma

0.00

0.0

1.0

—

113.29

—

(21494670) JAK2 gene exon 14 targeted mutation analysis in Blood or Tissue by Molecular genetics method

0.00

0.0

1.0

—

(3043405) Microscopic observation [Identifier] in Specimen by Non-gynecological cytology method

0.00

0.0

2.2

—

(3007847) Interleukin 2 Receptor Soluble [Units/volume] in Serum or Plasma

0.00

0.0

2.6

—

1125.80

—

(37021550) Renin [Units/volume] in Plasma --upright

0.00

0.0

1.6

—

199.12

—

(3029080) Hemoglobin [Entitic mass] in Reticulocytes

0.00

0.0

1.1

—

32.13

—

(3026515) Parvovirus B19 IgM Ab [Units/volume] in Serum

0.00

0.0

1.4

—

(3023323) Follitropin [Units/volume] in Serum or Plasma

1.00

0.00

1.0

1.7

22.86

19.34

iu/l

—

(3011648) Oxygen content in Venous blood

0.00

0.0

6.3

—

11.06

—

(3002079) Sodium [Moles/time] in 24 hour Urine

0.00

0.0

1.0

—

174.24

—

(3028300) Cannabinoids [Presence] in Urine

0.88

0.00

1.1

1.5

—

(40765089) Chromosome analysis panel - Blood by G-banded

0.00

0.0

1.0

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

0.95

0.00

1.2

1.0

—

(3003434) Protein [Mass/volume] in Pleural fluid

0.00

0.0

1.4

—

32.54

—

(3040370) OLANZapine [Moles/volume] in Serum or Plasma

0.00

0.0

2.6

—

139.60

—

(40768806) Pleura Pathology biopsy report

0.00

0.0

1.4

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.3

—

(3000764) Benzodiazepines [Presence] in Urine

0.89

-0.00

1.1

1.5

—

(3040359) Human coronavirus NL63 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(3004716) Salmonella sp identified in Stool by Organism specific culture

0.89

-0.00

1.6

1.4

—

(3036782) Glucose [Moles/volume] in Pleural fluid

0.00

-0.00

0.0

1.1

—

6.90

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

-0.00

0.0

1.1

—

(1001509) Gas and Carbon monoxide and Electrolytes panel - Arterial blood

0.00

-0.00

0.0

1.5

—

(40768800) Prostate Pathology biopsy report

0.00

-0.00

0.0

1.3

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.90

-0.00

1.2

1.5

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

1.7

—

(46236952) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (MDRD)/1.73 sq M

0.98

-0.00

1.8

2.4

—

78.61

—

(3022803) Oxygen [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.2

—

11.40

—

(44816752) ERBB2 gene copy number/nucleus in Tissue by FISH

0.00

-0.00

0.0

1.0

—

(3045156) Carbon dioxide [Partial pressure] adjusted to patient's actual temperature in Arterial blood

0.00

-0.00

0.0

3.2

—

4.75

—

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

0.97

-0.00

9.5

8.8

—

(3027008) Opiates [Presence] in Urine

0.89

-0.00

1.1

1.5

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

-0.00

0.0

1.7

—

(3045683) HLA typing for celiac disease panel - Blood or Tissue

0.00

-0.00

0.0

1.0

—

(3041642) Human coronavirus 229E RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

5.0

—

16.97

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.97

-0.00

1.7

1.6

—

(3038546) Human coronavirus OC43 RNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.7

—

Mortality – FinRegistry

↥

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

↥

Index endpoint: AB1_RELAP_FEVER_WIDE – Relapsing fevers, including avohilmo

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).

≡ Risteys

R14

FinnGen R13 + FinRegistry

FinnGen R12 + FinRegistry

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Relapsing fevers, including avohilmo

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Relapsing fevers, including avohilmo (AB1_RELAP_FEVER_WIDE)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints