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Chagas' disease

AB1_CHAGA

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

557745

1. Apply sex-specific rule

None

557745

2. Check conditions

None

557745

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 B57
  • Hospital discharge: ICD-9 086[0-2]
  • Hospital discharge: ICD-8 08[6]
  • Cause of death: ICD-10 B57
  • Cause of death: ICD-9 086[0-2]
  • Cause of death: ICD-8 08[6]

2 out of 7 registries used, show all original rules.

9

4. Check minimum number of events

None

9

5. Include endpoints

None

9

6. Filter based on genotype QC (FinnGen only)

9

Control definitions (FinnGen only)

Control exclude
AB1_PROTOZOAL

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

Not enough data for upset plot.

Not enough data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 77 33 43
Only index persons 58 29 29
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population 49.85 50.48 49.46
Only index persons 37.25 43.41 31.10

-FinnGen-

Key figures

All Female Male
Number of individuals 9 5 -
Unadjusted period prevalence (%) 0.00 0.00 -
Median age at first event (years) 51.05 55.25 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
0
35
0.00
1.61
0.0
5.0
—
0.00
—
0
10
9
55
+∞
1.61
7.1
5.0
—
—
—
0
0
9
79
+∞
0.23
6.8
5.8
37.89
39.41
mmol/mol
—
9
71
9
80
+∞
0.23
36.3
18.2
139.89
139.89
mmol/l
—
9
80
0
10
0.00
0.23
0.0
1.2
—
—
—
0
0
0
12
0.00
0.23
0.0
4.9
—
—
—
0
0
9
78
+∞
0.23
5.2
5.3
5.78
5.82
mmol/l
—
9
69
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
4.6
—
14.44
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
26.20
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
5.2
—
31.00
—
0
5
0
5
0.00
0.00
0.0
6.4
—
28.62
—
0
5
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.2
—
8.08
—
0
6
0
6
0.00
-0.00
0.0
3.2
—
5.18
—
0
6
0
6
0.00
-0.00
0.0
7.5
—
7.41
—
0
6
0
9
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.1
—
—
—
0
0
9
83
+∞
-0.00
34.9
21.0
110.11
87.73
umol/l
—
9
83
9
83
+∞
-0.00
6.0
6.6
2.61
2.63
mmol/l
—
9
74
0
6
0.00
-0.00
0.0
5.5
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint AB1_CHAGA and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have AB1_CHAGA.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: AB1_CHAGA – Chagas' disease

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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