Traumatic secondary and recurrent haemorrhage

ST19_TRAUMAT_SECONDA_RECUR_HAEMORRHAGE

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — T79.2 Cause of death: ICD-10 — T79.2 2 out of 7 registries used, show all original rules.	75
4. Check minimum number of events None	75
5. Include endpoints None	75
6. Filter based on genotype QC (FinnGen only)	59

Control definitions (FinnGen only)

Control exclude: ST19_ALIQU_COMPLICATI_PRAECO_TRAUMAT

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF4
Parent code in ICD-10: T79
Name in latin: Haemorrhagia traumatica secundaria et/sive recurrens

NAME	ST19_TRAUMAT_SECONDA_RECUR_HAEMORRHAGE
CONTROL_EXCLUDE	ST19_ALIQU_COMPLICATI_PRAECO_TRAUMAT
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	T792
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	T792
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Traumatic secondary and recurrent haemorrhage based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	59	30	29
Unadjusted period prevalence (%)	0.01	0.01	0.01
Median age at first event (years)	69.71	70.12	69.28

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
63: Matched controls
630

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

T79.2

ICD-10 Finland

Traumatic secondary and recurrent haemorrhage

+∞

90.4

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

4.7

8.4

162

X59

ICD-10 Finland

Exposure to unspecified factor

4.9

8.2

B01AA03

ATC

warfarin; systemic

4.2

7.2

106

X58

ICD-10 Finland

Exposure to other specified factors

5.0

7.2

WX700

NOMESCO Finland

Respiratory and circulatory monitoring

4.5

6.5

PG1PT

NOMESCO Finland

Extensive endovascular embolisation for bleeding with radiological guidance not elsewhere classified

+∞

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3042936) Bacteria identified in Isolate by Culture

3.16

4.09

3.1

2.4

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

7.45

3.80

1.6

1.5

—

(3047007) Chlamydophila sp Ab [Presence] in Serum

9.30

3.33

1.3

1.1

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

5.94

3.31

1.8

1.3

—

(3012544) pH of Venous blood

3.06

3.27

3.7

3.3

7.37

7.38

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

2.96

3.21

3.2

1.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

247

2.52

3.10

4.4

3.0

—

estimate

—

(3014576) Chloride [Moles/volume] in Serum or Plasma

2.72

3.08

6.0

6.6

103.50

103.29

mmol/l

0.08

(3016407) Fibrinogen [Mass/volume] in Platelet poor plasma by Coagulation assay

5.90

2.96

3.1

4.1

4.27

3.10

g/l

—

(3032080) INR in Blood by Coagulation assay

289

2.54

2.95

54.3

18.3

1.66

1.31

inr

2.03

246

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

125

2.49

2.86

4.5

2.6

—

(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay

4.66

2.78

7.9

2.5

0.28

0.41

iu/ml

—

(3044640) Blood type and Crossmatch panel - Blood

178

2.31

2.65

5.0

2.6

—

(36033641) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Rapid immunoassay

7.63

2.59

1.2

1.4

—

(3000515) Antithrombin actual/normal in Platelet poor plasma by Chromogenic method

4.78

2.55

2.0

3.3

101.71

91.69

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

6.67

2.41

1.0

1.1

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

105

2.33

2.29

7.2

2.8

0.85

0.81

mmol/l

0.81

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

2.50

2.20

3.5

1.7

—

(3023368) Bacteria identified in Blood by Culture

191

2.09

2.12

9.2

4.7

—

(3026008) Bacteria identified in Urine by Culture

179

2.02

1.91

4.6

3.1

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

2.24

1.77

8.9

3.8

1.02

1.01

mmol/l

0.02

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

100

2.12

1.76

3.3

1.7

—

(3019250) Coagulation factor VIII activity actual/normal in Platelet poor plasma by Coagulation assay

4.08

1.75

2.8

3.8

219.20

227.69

—

(3019977) pH of Arterial blood

2.18

1.67

9.8

6.8

7.41

7.43

—

(3022250) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma by Lactate to pyruvate reaction

2.18

1.59

6.0

5.2

270.07

239.73

u/l

0.66

(42870588) Differential panel, method unspecified - Blood

171

1.89

1.58

8.1

5.4

—

(3022313) Gas panel - Capillary blood

2.90

1.47

4.7

2.8

—

(3019150) Specific gravity of Urine by Refractometry

117

1.89

1.39

5.5

5.2

1.02

kg/l

0.84

(3007853) Bacteria identified in Skin by Aerobe culture

2.08

1.36

2.6

1.6

—

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

2.92

1.31

2.8

1.6

—

(3051552) Clostridioides difficile toxin genes [Presence] in Stool by NAA with probe detection

2.40

1.30

1.8

1.4

—

(3049717) Cytology report of Urine Cyto stain

2.77

1.24

1.6

3.0

—

(3010517) Carboxyhemoglobin/Hemoglobin.total in Venous blood

2.20

1.20

3.0

2.4

2.07

1.42

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

2.14

1.19

1.8

2.6

0.21

g/l

—

(3022948) Iron [Moles/volume] in Serum or Plasma

107

1.81

1.15

3.8

2.1

11.06

13.00

umol/l

0.57

100

(586526) SARS-CoV-2 (COVID-19) RNA [Presence] in Nasopharynx by NAA with probe detection

2.41

1.14

1.7

1.3

—

(3000494) Fungus identified in Specimen by Culture

1.98

1.14

2.7

1.4

—

(3015736) pH of Urine

214

1.66

1.12

5.0

4.2

6.50

6.24

0.53

114

(3019060) Gas panel - Arterial blood

2.16

1.11

3.0

3.2

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

1.83

1.09

3.8

2.0

16.19

23.82

2.11

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

2.19

1.06

2.4

1.4

—

(1761868) Lipid panel - Serum or Plasma

189

0.55

1.03

5.1

3.6

—

(3003694) ABO and Rh group [Type] in Blood

137

1.67

1.00

1.5

—

(3000492) Spirometry study

1.97

0.98

1.4

1.6

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

2.00

0.97

3.3

1.7

—

(3013115) Eosinophils [#/volume] in Blood

279

1.57

0.94

13.3

6.5

0.18

0.20

e9/l

0.37

246

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.93

0.94

3.7

2.7

37.00

29.71

u/l

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

1.93

0.94

1.3

1.4

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.03

0.93

1.3

1.4

—

(3009261) Glucose [Presence] in Urine by Test strip

280

1.56

0.92

6.3

4.3

0.00

estimate

—

(36031861) Influenza virus A and B and SARS-CoV-2 (COVID-19) and Respiratory syncytial virus RNA panel - Respiratory system specimen by NAA with probe detection

2.18

0.92

3.5

1.4

—

(3021601) Nitrite [Presence] in Urine by Test strip

274

1.52

0.84

6.5

4.3

0.00

estimate

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.71

0.83

2.0

1.7

—

(3035350) Ketones [Presence] in Urine by Test strip

276

1.50

0.80

6.5

4.3

0.00

21.95

estimate

—

(42868678) Cholesterol non HDL [Moles/volume] in Serum or Plasma

0.00

0.79

0.0

1.9

—

3.53

—

(3022145) Colonoscopy Study observation

1.74

0.78

2.2

1.4

—

(43534045) MCM6 gene c.-13910C>T and -13915T>G [Identifier] in Blood or Tissue by Molecular genetics method Nominal

2.17

0.76

1.4

1.0

—

(3024889) Methemoglobin/Hemoglobin.total in Venous blood

1.89

0.75

2.9

2.4

0.50

0.66

—

(3000991) Gas panel - Venous blood

1.64

0.74

12.2

7.3

—

(3004588) Protein electrophoresis panel - Serum or Plasma

1.72

0.65

1.6

2.4

—

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

0.61

0.0

1.2

—

(3018418) pH of Serum or Plasma

182

1.42

0.58

5.7

3.9

7.41

7.39

1.16

136

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

1.61

0.56

3.5

2.9

6.90

11.84

umol/l

—

(3019800) Troponin T.cardiac [Mass/volume] in Serum or Plasma

251

1.37

0.54

4.4

4.6

329.90

57.52

ng/l

0.44

196

(3004789) Transferrin [Mass/volume] in Serum or Plasma

102

1.48

0.53

3.9

1.9

2.34

2.20

g/l

0.40

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.56

0.50

3.2

3.9

—

(3018095) Leukocytes [#/volume] in Urine

227

1.33

0.46

8.3

4.2

121.36

77.73

e6/l

0.17

183

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

1.56

0.42

13.8

6.1

24.36

25.39

mmol/l

—

(40760892) CBC W Ordered Manual Differential panel - Blood

125

1.38

0.42

16.9

5.6

—

(3017766) Complement C4 [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.3

—

0.22

—

(3000620) Complement C3 [Mass/volume] in Serum or Plasma

0.00

0.41

0.0

1.3

—

1.08

—

(3017044) Thyrotropin receptor Ab [Units/volume] in Serum

0.00

0.41

0.0

2.2

—

2.95

—

(3020891) Body temperature

1.47

0.37

2.8

3.4

36.92

36.97

°c

—

(3033319) Streptococcus pyogenes Ag [Presence] in Throat

1.44

0.36

1.3

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

284

1.26

0.34

3.1

3.0

—

(3012516) Albumin [Mass/volume] in Urine

177

1.28

0.33

4.9

3.1

63.74

49.00

mg/l

0.21

118

(3020682) Albumin/Creatinine [Ratio] in Urine

178

1.27

0.32

5.4

3.8

15.00

9.77

mg/mmol

0.30

113

(3048773) Triglyceride [Moles/volume] in Serum or Plasma --fasting

468

0.80

0.27

5.1

4.6

1.47

1.25

mmol/l

0.95

428

(3045783) Sodium and Potassium panel [Moles/volume] - Serum or Plasma

1.27

0.27

5.9

9.3

—

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

1.27

0.27

1.4

—

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

243

1.19

0.22

2.3

2.2

100.79

92.38

pmol/l

0.53

125

(3012477) Bordetella pertussis DNA [Presence] in Specimen by NAA with probe detection

0.00

0.21

0.0

1.3

—

(42868544) Hantavirus puumala IgM Ab [Presence] in Serum or Plasma by Immunofluorescence

0.00

0.21

0.0

1.1

—

(3023421) Hepatitis B virus surface Ab [Units/volume] in Serum

0.00

0.21

0.0

1.1

—

455.50

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.2

—

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.31

0.21

1.3

1.6

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

1.28

0.21

7.2

7.3

0.35

0.70

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

0.21

0.0

2.9

—

67.73

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

1.22

0.20

7.5

7.1

1.53

1.41

—

(3000850) Epithelial cells [#/volume] in Urine

162

0.83

0.19

4.4

3.0

5.14

3.76

e6/l

0.20

155

(4035726) Immunohistochemistry procedure

1.14

0.18

1.6

1.3

—

(3021589) Normoblasts [#/volume] in Blood

247

1.16

0.18

26.1

13.1

0.00

e9/l

0.93

208

(3002256) Pathology report gross observation

1.13

0.17

1.1

1.2

—

(3027945) Reticulocytes/Erythrocytes in Blood

1.20

0.16

5.4

3.4

2.13

1.76

—

(3018006) Microscopic observation [Identifier] in Cervix by Cyto stain.thin prep

1.10

0.09

2.0

1.4

—

(40768797) Stomach Pathology biopsy report

1.11

0.08

1.1

1.2

—

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

398

1.09

0.06

6.2

4.7

16.11

13.27

mm/h

0.59

361

(40758558) Short blood count panel - Blood

170

1.08

0.04

11.9

7.1

—

(40768804) Tissue Pathology biopsy report

211

1.07

0.03

2.7

2.1

—

(40761511) CBC panel - Blood by Automated count

517

1.03

0.00

36.1

16.4

—

(42529215) Follitropin [Units/volume] in Serum or Plasma by Immunoassay

0.00

0.0

1.7

—

36.52

—

(3011166) Borrelia burgdorferi Ab [Presence] in Cerebral spinal fluid

0.00

0.0

1.0

—

(44816844) Macroprolactin [Units/volume] in Serum or Plasma

0.00

0.0

1.5

—

208.33

—

(3043238) Trisomy 21 risk [Likelihood] in Fetus

0.00

0.0

1.8

—

(3035320) C reactive protein [Mass/volume] in Body fluid

0.00

0.0

2.2

—

65.50

—

(43055089) Myosin Ab [Presence] in Serum or Plasma by Immunoblot

0.00

0.0

1.0

—

(3053028) Streptococcus sp identified in Specimen by Organism specific culture

0.00

-0.00

0.0

1.0

—

(3028707) Methadone [Presence] in Urine by Screen method

0.00

-0.00

0.0

1.4

—

(40760543) Extractable nuclear Ab [Presence] in Serum by Immunoblot

0.00

-0.00

0.0

1.0

—

(3038026) Centromere Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.2

—

(3011288) Drugs identified in Urine by Screen method Nominal

0.00

-0.00

0.0

1.4

—

(4062490) Immunoglobulin typing, IgG

0.00

-0.00

0.0

1.2

—

(3008757) Leukocyte morphology finding [Identifier] in Blood

0.00

-0.00

0.0

3.7

—

(3024135) Streptococcus.beta-hemolytic [Presence] in Throat by Organism specific culture

1.00

-0.00

1.4

1.5

—

(3005570) Glucose [Moles/volume] in Urine

0.00

-0.00

0.0

3.3

—

(40768441) Liver Pathology biopsy report

0.00

-0.00

0.0

1.2

—

(3032773) Endomysium IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3016018) Differential panel - Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

-0.00

0.0

1.1

—

(3020565) Legionella pneumophila DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.4

—

(40764999) Glomerular filtration rate [Volume Rate/Area] in Serum, Plasma or Blood by Creatinine-based formula (CKD-EPI)/1.73 sq M

490

1.00

-0.00

36.0

19.1

71.79

76.28

ml/min/173m2

0.61

463

(3006257) Acetylcholine receptor Ab [Moles/volume] in Serum

0.00

-0.00

0.0

1.4

—

(3014973) Borrelia burgdorferi IgM Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3003265) Liver kidney microsomal Ab [Titer] in Serum by Immunofluorescence

0.00

-0.00

0.0

1.2

—

(3012447) Hantavirus puumala IgG Ab [Titer] in Serum

0.00

-0.00

0.0

1.2

—

(3047352) Trisomy 18 risk [Likelihood] in Fetus

0.00

-0.00

0.0

1.6

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

2.1

—

5.11

—

(3025018) Bordetella pertussis Ab [Titer] in Serum

0.00

-0.00

0.0

1.0

—

(3010380) Borrelia burgdorferi IgG Ab [Units/volume] in Cerebral spinal fluid

0.00

-0.00

0.0

1.0

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.6

—

(3016436) Lactate dehydrogenase [Enzymatic activity/volume] in Serum or Plasma

0.00

-0.00

0.0

3.4

—

239.40

—

Mortality – FinRegistry

↥

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

↥

Index endpoint: ST19_TRAUMAT_SECONDA_RECUR_HAEMORRHAGE – Traumatic secondary and recurrent haemorrhage

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

≡ Risteys

R14

FinnGen R13 + FinRegistry

FinnGen R12 + FinRegistry

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Traumatic secondary and recurrent haemorrhage

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Traumatic secondary and recurrent haemorrhage (ST19_TRAUMAT_SECONDA_RECUR_HAEMORRHAGE)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints