Gastric ulcer - Acute with haemorrhage, drug-induced

GASTRIC_ULCER_ACUTE_W_HAEMORRHAGE

No definition available.

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps	FinnGen
Phenotype data	557745
1. Apply sex-specific rule None	557745
2. Check conditions None	557745
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ATC codes for adverse effects of Drugs — ANY Hospital discharge: ICD-10 — K25.0# 1 out of 7 registries used, show all original rules.	70
4. Check minimum number of events None	70
5. Include endpoints None	70
6. Filter based on genotype QC (FinnGen only)	63

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy: C
First used in FinnGen datafreeze: DF5

NAME	GASTRIC_ULCER_ACUTE_W_HAEMORRHAGE
CONTROL_EXCLUDE
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC	ANY
HD_ICD_10	K250
HD_ICD_9
HD_ICD_8
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10
COD_ICD_9
COD_ICD_8
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Gastric ulcer - Acute with haemorrhage, drug-induced based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

This endpoint is excluded (not available in FinRegistry).

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	63	16	47
Unadjusted period prevalence (%)	0.02	0.01	0.02
Median age at first event (years)	61.87	58.29	63.09

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
66: Matched controls
660

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

K25.0

ICD-10 Finland

Gastric ulcer, Acute with haemorrhage

+∞

84.6

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

5.9

11.7

137

UJD02

NOMESCO Finland

Gastroscopy

14.1

10.6

A02BC01

ATC

omeprazole; systemic

5.1

9.9

133

A02BC03

ATC

lansoprazole; oral

4.7

9.0

141

K92.0

ICD-10 Finland

Haematemesis

11.9

6.9

JDA32

NOMESCO Finland

Endoscopic injection in stomach or pylorus

77.0

6.5

K26.0

ICD-10 Finland

Duodenal ulcer, acute with haemorrhage

+∞

6.3

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(36305247) Microscopic observation [Identifier] in Isolate by Gram stain

5.90

2.25

1.6

1.2

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.00

2.18

0.0

5.6

—

31.75

—

(40767503) Oxygen content in Capillary blood by calculation

4.07

1.75

5.2

2.2

15.70

16.22

—

(3018251) Fasting glucose [Moles/volume] in Serum or Plasma

414

0.56

1.48

6.0

5.6

6.70

6.17

mmol/l

0.23

364

(3005702) Mycobacterium sp identified in Specimen by Organism specific culture

3.29

1.46

2.4

1.1

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

2.64

1.33

1.2

1.5

—

(3009201) Thyrotropin [Units/volume] in Serum or Plasma

389

0.58

1.33

5.2

4.8

1.79

2.05

mu/l

0.69

334

(3008486) Thyroxine (T4) free [Moles/volume] in Serum or Plasma

306

0.58

1.24

4.5

3.8

14.94

15.08

pmol/l

0.10

264

(3020059) Calcium [Moles/volume] corrected for albumin in Serum or Plasma

121

0.45

1.21

3.2

3.0

2.54

2.46

mmol/l

—

106

(3019284) Hepatitis B virus surface Ag [Presence] in Serum

2.19

1.20

3.9

1.5

—

(3017143) Hepatitis C virus Ab [Presence] in Serum

2.40

1.14

3.3

1.7

—

(3015377) Calcium [Moles/volume] in Serum or Plasma

171

0.51

1.12

2.2

3.1

2.34

mmol/l

—

145

(3034780) Angiotensin converting enzyme [Enzymatic activity/volume] in Serum or Plasma

2.37

1.05

1.2

1.9

61.40

42.50

u/l

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

1.96

0.98

6.7

3.5

—

(3044938) Influenza virus A RNA [Presence] in Specimen by NAA with probe detection

1.67

0.85

2.1

1.8

—

(46235355) HIV 1 and 2 tests - Meaningful Use set

1.76

0.82

3.8

1.7

—

(3022313) Gas panel - Capillary blood

0.00

0.81

0.0

5.0

—

(3042936) Bacteria identified in Isolate by Culture

1.68

0.75

1.8

1.9

—

(3019060) Gas panel - Arterial blood

1.84

0.74

2.6

3.7

—

(40760892) CBC W Ordered Manual Differential panel - Blood

1.60

0.71

8.0

5.3

—

(3038288) Influenza virus B RNA [Presence] in Specimen by NAA with probe detection

1.69

0.70

2.1

1.8

—

(40768797) Stomach Pathology biopsy report

1.69

0.66

1.3

—

(40761536) Microorganisms panel - Urine sediment

1.72

0.62

5.2

3.9

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.61

0.0

1.3

—

(3008909) Norovirus RNA [Presence] in Stool by NAA with probe detection

0.00

0.61

0.0

1.0

—

(3024950) Chlamydia trachomatis DNA [Presence] in Urine by NAA with probe detection

0.00

0.61

0.0

1.6

—

(40761511) CBC panel - Blood by Automated count

432

0.72

0.60

29.9

16.9

—

(3013742) Prealbumin [Mass/volume] in Serum or Plasma

1.73

0.58

2.3

2.4

0.24

0.21

g/l

—

(40768804) Tissue Pathology biopsy report

176

0.67

0.55

2.4

2.3

—

(3007853) Bacteria identified in Skin by Aerobe culture

1.47

0.54

2.0

1.7

—

(3043924) Respiratory syncytial virus RNA [Identifier] in Specimen by NAA with probe detection

1.54

0.52

2.0

1.7

—

(3013512) EKG study

195

0.70

0.51

2.9

4.3

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

216

1.34

0.47

2.5

—

estimate

—

(3001784) Prostate Specific Ag Free/Prostate specific Ag.total in Serum or Plasma

212

0.73

0.45

5.1

5.2

19.67

22.46

—

121

(43054914) Glucose tolerance 2 hours panel - Serum or Plasma

1.61

0.43

1.2

1.5

—

(3007628) Bicarbonate [Moles/volume] standard in Venous blood

1.51

0.41

2.0

4.9

23.78

24.00

mmol/l

—

(3003510) Neisseria gonorrhoeae DNA [Presence] in Urine by NAA with probe detection

0.00

0.40

0.0

1.3

—

(3029187) Natriuretic peptide.B prohormone N-Terminal [Mass/volume] in Serum or Plasma

207

0.76

0.37

4.1

3.4

2911.13

1848.93

ng/l

0.33

168

(3009508) Creatinine [Moles/volume] in Urine

165

1.30

0.37

3.5

3.2

7.18

7.52

mmol/l

0.17

135

(3018010) Neutrophils/Leukocytes in Blood

213

1.28

0.37

6.2

5.7

58.90

59.55

0.07

200

(3003694) ABO and Rh group [Type] in Blood

106

0.72

0.32

1.4

—

(3014111) Lactate [Moles/volume] in Serum or Plasma

1.33

0.31

1.9

9.6

1.65

1.47

mmol/l

—

(3037467) Urinalysis macro (dipstick) panel - Urine

314

0.81

0.30

4.8

4.9

—

(3002030) Lymphocytes/Leukocytes in Blood

220

1.22

0.27

6.2

5.7

27.12

25.51

0.19

206

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

116

1.26

0.24

2.1

2.2

—

(3026008) Bacteria identified in Urine by Culture

154

1.23

0.24

3.7

3.5

—

(36304419) Bacteria [Presence] in Urine

127

1.23

0.22

3.1

3.5

—

estimate

—

(3010521) Mycoplasma pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

0.21

0.0

1.3

—

(3045716) Anion gap in Serum or Plasma by calculation

0.00

0.21

0.0

2.1

—

8.72

—

(3039443) Prostate specific Ag panel - Serum or Plasma

0.00

0.21

0.0

1.7

—

(3043109) Cytology report of Tissue fine needle aspirate Cyto stain

0.00

0.21

0.0

1.1

—

(40760847) Basement membrane Ab [Titer] in Serum by Immunofluorescence

0.00

0.21

0.0

1.7

—

(3008898) HLA-B27 [Presence]

0.00

0.21

0.0

1.0

—

(3046524) Influenza virus A Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

2.1

—

(3043362) Influenza virus B Ag [Presence] in Nasopharynx by Immunoassay

0.00

0.21

0.0

2.1

—

(37019628) Gastrointestinal bacterial pathogens panel - Stool by NAA with probe detection

0.00

0.21

0.0

1.2

—

(3025941) Bacteria identified in Stool by Culture

0.00

0.21

0.0

1.2

—

(4094501) Cardiovascular stress test using bicycle ergometer

0.00

0.21

0.0

1.2

—

(3013603) Prostate specific Ag [Mass/volume] in Serum or Plasma

266

0.85

0.21

5.2

6.1

1.78

2.50

ug/l

0.75

229

(3019069) Monocytes/Leukocytes in Blood

215

1.18

0.20

6.4

5.7

9.49

9.10

0.26

201

(3000991) Gas panel - Venous blood

1.22

0.20

2.0

12.4

—

(3009261) Glucose [Presence] in Urine by Test strip

254

0.85

0.18

4.0

4.5

0.00

estimate

—

(1761868) Lipid panel - Serum or Plasma

120

1.21

0.18

5.1

4.0

—

(3013721) Aspartate aminotransferase [Enzymatic activity/volume] in Serum or Plasma

130

1.20

0.17

3.3

2.9

117.53

32.69

u/l

0.45

122

(3007220) Creatine kinase [Enzymatic activity/volume] in Serum or Plasma

156

0.87

0.11

1.6

2.1

171.57

169.34

u/l

0.01

149

(3013826) Glucose [Moles/volume] in Serum or Plasma

293

1.11

0.10

5.7

5.6

6.76

6.92

mmol/l

0.16

284

(3022096) Basophils/Leukocytes in Blood

214

1.11

0.10

6.3

5.7

0.57

0.58

0.06

198

(3016417) Amylase.pancreatic [Enzymatic activity/volume] in Serum or Plasma

1.15

0.10

2.0

2.3

24.80

33.49

u/l

—

(3020630) Protein [Mass/volume] in Serum or Plasma

1.15

0.09

2.3

2.0

65.93

67.23

g/l

—

(3012516) Albumin [Mass/volume] in Urine

166

1.12

0.09

3.6

3.3

133.56

103.92

mg/l

—

118

(3013707) Erythrocyte sedimentation rate [Velocity] in Red Blood Cells by Westergren method

335

0.91

0.08

3.7

4.4

16.59

14.99

mm/h

0.18

302

(40758558) Short blood count panel - Blood

143

0.89

0.08

8.6

6.9

—

(3006504) Eosinophils/Leukocytes in Blood

216

1.10

0.08

6.1

5.6

2.55

2.80

0.30

201

(3016431) Calcium.ionized [Moles/volume] adjusted to pH 7.4 in Serum or Plasma

254

0.91

0.08

10.0

7.5

1.21

1.20

mmol/l

0.32

215

(3021601) Nitrite [Presence] in Urine by Test strip

252

0.93

0.06

3.9

4.4

0.00

estimate

—

(3035350) Ketones [Presence] in Urine by Test strip

252

0.93

0.06

4.0

4.5

0.00

estimate

—

(706163) SARS-CoV-2 (COVID-19) RNA [Presence] in Respiratory system specimen by NAA with probe detection

190

1.08

0.04

2.6

2.5

—

(3015736) pH of Urine

200

0.93

0.04

3.7

4.2

5.89

6.23

—

109

(43054903) Holo-transcobalamin II [Moles/volume] in Serum

222

1.06

0.02

2.2

2.5

94.23

89.75

pmol/l

0.20

124

(3044640) Blood type and Crossmatch panel - Blood

154

1.05

0.00

2.9

2.4

—

(3023368) Bacteria identified in Blood by Culture

174

1.05

0.00

5.8

4.4

—

(3020682) Albumin/Creatinine [Ratio] in Urine

174

1.05

0.00

4.8

4.1

36.29

20.06

mg/mmol

—

116

(3029287) Urinalysis microscopic panel [#/volume] - Urine by Automated count

191

0.99

0.00

2.9

3.5

—

(3029937) Albumin [Presence] in Urine by Test strip

147

1.03

0.00

4.5

3.9

0.00

0.05

estimate

—

(42870588) Differential panel, method unspecified - Blood

155

1.04

0.00

5.6

5.3

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

195

0.96

0.00

4.2

4.6

0.00

0.07

estimate

—

(3041096) Erythrocytes [Presence] in Urine by Automated

134

0.96

0.00

3.8

4.3

0.00

estimate

—

(3045788) Cell count panel - Pleural fluid

0.00

0.0

1.2

—

(3029075) Extractable nuclear Ab panel - Serum

0.00

0.0

1.0

—

(3028369) Herpes simplex virus 1+2 DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.6

—

(3029511) Human papilloma virus DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.2

—

(21494890) Protein electrophoresis panel - 24 hour Urine

0.00

0.0

1.3

—

(3005988) Vibrio sp identified in Specimen by Organism specific culture

0.00

0.0

1.2

—

(3002032) Base excess in Venous blood by calculation

0.96

0.00

1.8

4.8

0.93

1.50

mmol/l

—

(3044927) Protein electrophoresis panel - Urine

0.00

0.0

1.0

—

(3041423) Sjogrens syndrome-A extractable nuclear 60kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(3032699) Streptococcus pneumoniae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(3041067) Sjogrens syndrome-A extractable nuclear 52kD Ab [Units/volume] in Serum

0.00

0.0

1.0

—

(40758897) Direct antiglobulin test.IgG specific reagent [Presence] on Red Blood Cells

0.00

0.0

1.0

—

(40764126) Parainfluenza virus RNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

1.4

—

(21493466) Plesiomonas shigelloides DNA [Presence] in Stool by NAA with non-probe detection

0.00

0.0

1.2

—

(3011371) Neisseria gonorrhoeae DNA [Presence] in Specimen by NAA with probe detection

0.00

0.0

2.0

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

2.0

—

(40758895) Direct antiglobulin test.complement C3d specific reagent [Presence] on Red Blood Cells

0.00

0.0

1.0

—

(4146454) Self-monitoring of blood glucose

0.00

0.0

2.8

—

(3018387) Mycoplasma pneumoniae IgG Ab [Units/volume] in Serum

0.00

-0.00

0.0

1.3

—

(42529200) Cancer Ag 15-3 [Units/volume] in Serum or Plasma by Immunoassay

0.00

-0.00

0.0

2.7

—

123.67

—

(3044242) Glucose [Moles/volume] in Arterial blood

0.00

-0.00

0.0

1.8

—

10.20

—

(3012202) Varicella zoster virus DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.5

—

(3005785) Creatine kinase.MB [Mass/volume] in Serum or Plasma

1.02

-0.00

2.2

2.1

5.97

4.85

ug/l

—

(3005772) Bilirubin.conjugated [Moles/volume] in Serum or Plasma

0.98

-0.00

2.4

2.5

4.80

8.63

umol/l

—

(3019601) Blood group antibody investigation [Interpretation] in Plasma or RBC

0.00

-0.00

0.0

1.2

—

(3021387) Prolactin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.7

—

507.02

—

(3021952) Alkaline phosphatase isoenzymes [Enzymatic activity/volume] in Serum or Plasma by Heat stability

0.00

-0.00

0.0

1.2

—

(3003458) Phosphate [Moles/volume] in Serum or Plasma

0.91

-0.00

22.4

6.3

1.11

1.06

mmol/l

—

(3000093) Morphology [Interpretation] in Blood Narrative

0.00

-0.00

0.0

1.3

—

(3004616) Nuclear Ab [Presence] in Serum

0.00

-0.00

0.0

1.0

—

(3004451) EKG impression Narrative

0.00

-0.00

0.0

1.2

—

(3017732) Neutrophils [#/volume] in Blood

1.02

-0.00

1.8

3.3

6.50

4.41

e9/l

—

(3006588) Cancer Ag 15-3 [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

2.3

—

111.57

—

(3006093) Chlamydia trachomatis DNA [Presence] in Specimen by NAA with probe detection

0.00

-0.00

0.0

1.9

—

(3017817) Protein [Mass] in Urine collected for unspecified duration

0.00

-0.00

0.0

1.8

—

1189.67

—

(3027545) Mycoplasma pneumoniae Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.7

—

(3017354) Segmented neutrophils/Leukocytes in Blood

0.00

-0.00

0.0

1.3

—

60.67

—

(3015816) F5 gene p.Arg506Gln [Presence] in Blood or Tissue by Molecular genetics method

0.00

-0.00

0.0

1.0

—

(3000494) Fungus identified in Specimen by Culture

0.92

-0.00

1.0

1.4

—

(3003327) Ova and parasites identified in Stool by Light microscopy

0.00

-0.00

0.0

1.6

—

(3013527) Hepatitis B virus core IgM Ab [Presence] in Serum

0.00

-0.00

0.0

1.1

—

(3014702) Chromogranin A [Moles/volume] in Serum or Plasma

0.00

-0.00

0.0

3.2

—

4.53

—

(1175715) Chlamydophila pneumoniae IgM Ab [Presence] in Serum by Immunoassay

0.00

-0.00

0.0

1.3

—

(3009214) Lutropin [Units/volume] in Serum or Plasma

0.00

-0.00

0.0

1.4

—

7.06

—

Mortality – FinRegistry

↥

This endpoint is excluded (not available in FinRegistry).

Relationships between endpoints

↥

Index endpoint: GASTRIC_ULCER_ACUTE_W_HAEMORRHAGE – Gastric ulcer - Acute with haemorrhage, drug-induced

GWS hits: -

This endpoint is excluded (not available in FinRegistry).

≡ Risteys

R14

FinnGen R13 + FinRegistry

FinnGen R12 + FinRegistry

FinnGen R11 + FinRegistry

FinnGen R10 + FinRegistry

FinnGen R10

FinnGen R9

FinnGen R8

FinnGen R7

FinnGen R6

FinnGen R5

FinnGen R4

FinnGen R3

Gastric ulcer - Acute with haemorrhage, drug-induced

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

All original rules

Similar endpoints

Case counts by codes

Upset plot

Case counts by code for Gastric ulcer - Acute with haemorrhage, drug-induced (GASTRIC_ULCER_ACUTE_W_HAEMORRHAGE)

Summary Statistics

-FinRegistry-

-FinnGen-

Key figures

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

Matched cohort

LabWAS

Mortality – FinRegistry

Relationships between endpoints