This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

K11_HYPOPLASIA_ENAMEL

Nutritional and metabolic disorders in diseases classified elsewhere

Endpoint Browser

E4_METABINOTH

No definition available.

Suggest a new description

Endpoint definition

↥

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — E90* Cause of death: ICD-10 — E90* 2 out of 7 registries used, show all original rules.	14
4. Check minimum number of events None	14
5. Include endpoints None	14
6. Filter based on genotype QC (FinnGen only)	14

Control definitions (FinnGen only)

Control exclude: E4_METABOLIA

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2

NAME	E4_METABINOTH
CONTROL_EXCLUDE	E4_METABOLIA
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	E90
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	E90
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Nutritional and metabolic disorders in diseases classified elsewhere based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	84	39	45
Only index persons	65	34	31
Unadjusted period prevalence (%)
Whole population	0.00	0.00	0.00
Only index persons	0.00	0.00	0.00
Median age at first event (years)
Whole population	-	51.60	30.74
Only index persons	51.07	51.89	50.18

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	14	7	7
Unadjusted period prevalence (%)	0.00	0.00	0.00
Median age at first event (years)	21.55	41.27	1.82

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

No data available

LabWAS

↥

N Cases

N Controls

-log₁₀(p)

cases

controls

cases

controls

unit

-log₁₀(p)

N cases

N controls

(3026250) Tacrolimus [Mass/volume] in Blood

+∞

5.53

50.8

0.0

6.10

—

ug/l

—

(3027945) Reticulocytes/100 erythrocytes in Blood

13.53

4.64

8.4

9.9

1.17

1.52

—

(3048929) Epstein Barr virus Ab [Presence] in Serum

14.03

4.13

2.3

2.1

—

(40763571) Iron/Transferrin [Ratio] in Serum or Plasma

12.57

3.92

13.6

4.3

19.29

18.70

—

(3026493) Urate [Moles/volume] in Serum or Plasma

10.07

3.74

15.4

3.6

285.00

318.63

umol/l

—

(3012095) Magnesium [Moles/volume] in Serum or Plasma

9.41

3.59

28.8

11.4

0.77

0.80

mmol/l

—

(3030366) Cystatin C [Mass/volume] in Serum or Plasma

10.37

3.54

41.1

23.5

1.43

0.90

mg/l

—

(3004789) Transferrin [Mass/volume] in Serum or Plasma

10.37

3.54

12.7

3.4

2.47

2.64

g/l

—

(3007844) Epstein Barr virus capsid IgM Ab [Units/volume] in Serum by Immunoassay

11.96

3.44

2.5

2.1

—

(40760892) CBC W Ordered Manual Differential panel - Blood

11.96

3.44

18.7

3.0

—

(3041096) Erythrocytes [Presence] in Urine by Automated

7.02

2.95

12.1

1.7

—

(3014326) Insulin-like growth factor-I [Moles/volume] in Serum or Plasma

10.23

2.79

4.2

5.7

21.60

22.57

nmol/l

—

(21492711) Cytomegalovirus IgG Ab avidity [Presence] in Serum or Plasma by Immunoassay

10.23

2.79

2.4

1.1

—

(3015635) Cytomegalovirus IgM Ab [Units/volume] in Serum or Plasma

8.91

2.60

4.0

1.4

—

(3010130) Cytomegalovirus IgG Ab [Units/volume] in Serum or Plasma

8.91

2.60

4.0

1.5

—

(3017918) Cytomegalovirus IgG Ab [Titer] in Serum or Plasma

8.91

2.60

4.0

1.4

—

(40763086) Leukocyte esterase [Presence] in Urine by Automated test strip

5.53

2.49

14.1

1.9

—

(3018677) aPTT in Platelet poor plasma by Coagulation assay

5.90

2.46

5.7

4.4

30.43

30.65

—

(3002032) Base excess in Venous blood by calculation

5.26

2.35

24.0

8.9

0.46

1.27

mmol/l

—

(3012544) pH of Venous blood

5.26

2.35

24.1

8.9

—

(36304419) Bacteria [Presence] in Urine

5.13

2.33

7.2

5.3

—

(3000991) Gas panel - Venous blood

5.03

2.26

21.9

9.4

—

(3011397) Hemoglobin [Presence] in Urine by Test strip

4.82

2.18

7.5

3.6

—

(3001079) Blood group antibody screen [Presence] in Serum or Plasma

4.02

1.77

4.6

3.6

—

(3016293) Bicarbonate [Moles/volume] in Serum or Plasma

3.09

1.26

22.9

8.5

23.97

24.83

mmol/l

—

(3044640) Blood type and Crossmatch panel - Blood

2.97

1.08

4.5

2.8

—

(3033658) Prothrombin time (PT) actual/Normal

2.97

1.08

22.5

8.0

97.17

88.86

—

(3022313) Gas panel - Capillary blood

2.51

0.95

18.5

5.0

—

(1761868) Lipid panel - Serum or Plasma

2.66

0.85

6.4

2.1

—

(3026910) Gamma glutamyl transferase [Enzymatic activity/volume] in Serum or Plasma

2.53

0.81

10.3

4.4

40.89

30.26

u/l

—

(46236098) ABO and Rh group [Type] in Blood by Confirmatory method

2.42

0.80

4.6

2.7

—

(3003694) ABO and Rh group [Type] in Blood

2.21

0.74

1.4

1.6

—

(3046870) Tissue transglutaminase IgG Ab [Units/volume] in Serum

0.00

0.44

0.0

1.1

—

(40758558) Short blood count panel - Blood

1.85

0.42

18.9

11.4

—

(42870588) Differential panel, method unspecified - Blood

1.41

0.24

41.4

9.1

—

(3016502) Oxygen saturation in Arterial blood

0.00

0.22

0.0

3.8

—

96.24

—

(3002256) Pathology report gross observation

0.00

0.22

0.0

1.0

—

(3000924) Streptococcus pyogenes [Presence] in Throat by Organism specific culture

0.00

0.22

0.0

1.6

—

(40762366) Oxygen capacity [Volume Fraction] in Arterial blood

0.00

0.0

3.9

—

(3002173) Hemoglobin [Mass/volume] in Arterial blood

0.00

0.0

3.6

—

132.67

—

(3022145) Colonoscopy Study observation

0.00

0.0

1.1

—

(21494755) Public health laboratory ask at order entry panel

0.00

0.0

1.0

—

(4010399)

0.00

0.0

1.3

—

(3028653) Carboxyhemoglobin/Hemoglobin.total in Arterial blood

0.00

0.0

5.4

—

1.09

—

(3027008) Opiates [Presence] in Urine

0.00

0.0

1.0

—

(3016879) Cocaine [Presence] in Urine

0.00

0.0

1.0

—

(3019225) pH of Specimen

0.00

0.0

4.2

—

(3027944) Amphetamines [Presence] in Urine

0.00

0.0

1.0

—

(42868674) Cholesterol in HDL/Cholesterol.total [Molar ratio] in Serum or Plasma

0.00

0.0

4.3

—

37.29

—

(36032419) SARS-CoV-2 (COVID-19) Ag [Presence] in Upper respiratory specimen by Immunoassay

0.00

0.0

2.6

—

(3002523) Influenza virus A Ag [Presence] in Specimen

0.00

0.0

1.2

—

(3048821) Cortisol [Moles/volume] in Serum or Plasma --post 1 mg dexamethasone PO overnight

0.00

0.0

1.2

—

(3019060) Gas panel - Arterial blood

0.00

0.0

1.6

—

(3028300) Cannabinoids [Presence] in Urine

0.00

0.0

1.0

—

(3014765) Yersinia sp identified in Stool by Organism specific culture

0.00

0.0

1.0

—

(3001019) Free T4 and TSH panel - Serum or Plasma

0.00

0.0

1.2

—

(3019902) Methicillin resistant Staphylococcus aureus [Presence] in Specimen by Organism specific culture

0.00

0.0

2.0

—

(3000492) Spirometry study

0.00

0.0

1.6

—

(3005013) Prostate Specific Ag Free [Mass/volume] in Serum or Plasma

0.00

0.0

2.5

—

1.28

—

(3002109) Cholesterol in LDL/Cholesterol in HDL [Mass Ratio] in Serum or Plasma

0.00

0.0

1.3

—

(3014007) Fractional oxyhemoglobin in Arterial blood

0.00

0.0

5.4

—

95.06

—

(42529406) Shigella sp [Presence] in Stool by Culture

0.00

0.0

1.0

—

(3022621) pH of Urine by Test strip

0.00

0.0

1.8

—

(3021879) Hepatitis B virus core Ab [Presence] in Serum

0.00

0.0

1.4

—

(3006217) Methemoglobin/Hemoglobin.total in Arterial blood

0.00

0.0

5.4

—

0.67

—

(3044491) Cholesterol non HDL [Mass/volume] in Serum or Plasma

0.00

0.0

1.0

—

(1001926) Buprenorphine [Presence] in Urine by Screen method

0.00

0.0

1.0

—

(3008152) Bicarbonate [Moles/volume] in Arterial blood

0.00

0.0

3.0

—

26.70

—

(40768793) Breast Pathology biopsy report

0.00

0.0

1.0

—

(3003740) Influenza virus B Ag [Presence] in Specimen

0.00

0.0

1.2

—

(3006418) Campylobacter sp identified in Tissue by Organism specific culture

0.00

0.0

1.0

—

(3014218) Bicarbonate [Moles/volume] standard in Arterial blood

0.00

0.0

7.0

—

23.20

—

Mortality – FinRegistry

↥

Association

Association between endpoint E4_METABINOTH and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have E4_METABINOTH.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: E4_METABINOTH – Nutritional and metabolic disorders in diseases classified elsewhere

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

rg [CI]

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Nutritional and metabolic disorders in diseases classified elsewhere

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

LabWAS

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints