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Brain medulloblastoma, including Hilmo

C3_MEDULLOBLASTOMA_WIDE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

  • HLP_C3_MEDULLOBLASTOMA
13

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C71
  • Hospital discharge: ICD-9 191
  • Hospital discharge: ICD-8 191
  • Cause of death: ICD-10 C71
  • Cause of death: ICD-9 191
  • Cause of death: ICD-8 191
  • Cancer registry: Topography ICD-O-3 C71
  • Cancer registry: Morphology ICD-O-3 9470
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

13

4. Check minimum number of events

None

13

5. Include endpoints

13

6. Filter based on genotype QC (FinnGen only)

12

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE
Control conditions
not HLP_C3_MEDULLOBLASTOMA

Extra metadata

First used in FinnGen datafreeze
DF12

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: unknown.

No upset table: unknown.

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 12 11 -
Unadjusted period prevalence (%) 0.00 0.00 -
Median age at first event (years) 15.26 16.59 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

No data available

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
8
12
15.16
4.52
4.9
13.9
1.09
1.40
mmol/l
—
8
12
6
5
20.33
4.23
3.3
7.0
2.15
1.52
%
—
6
5
7
13
10.20
3.43
5.0
2.2
—
—
—
0
0
7
13
10.20
3.43
5.9
2.4
320.00
351.62
nmol/l
—
7
13
6
16
5.99
2.25
2.0
2.4
29.63
29.69
s
—
6
16
7
24
5.07
2.11
4.9
3.2
97.71
90.75
%
—
7
24
5
18
3.84
1.43
1.0
1.4
—
—
—
0
0
13
100
+∞
1.15
34.9
7.7
58.00
56.73
umol/l
0.08
13
100
6
31
2.71
1.00
46.0
5.2
—
—
—
0
0
0
27
0.00
0.89
0.0
1.8
—
44.38
—
0
22
0
21
0.00
0.67
0.0
1.3
—
—
—
0
0
13
109
+∞
0.67
20.8
6.5
—
—
—
0
0
0
16
0.00
0.44
0.0
1.3
—
—
—
0
0
0
14
0.00
0.44
0.0
5.2
—
308.29
—
0
14
0
17
0.00
0.44
0.0
1.6
—
—
—
0
0
0
17
0.00
0.44
0.0
1.6
—
—
—
0
0
0
17
0.00
0.44
0.0
1.6
—
—
—
0
0
6
78
0.57
0.42
4.7
5.0
—
—
—
0
0
5
35
1.69
0.29
1.4
1.9
—
—
—
0
0
5
37
1.57
0.28
2.2
1.9
—
—
—
0
0
8
64
1.64
0.25
3.6
3.0
294.75
44.91
ug/l
—
8
58
8
67
1.50
0.24
3.0
4.0
11.63
10.11
mm/h
—
8
61
0
12
0.00
0.22
0.0
1.3
—
—
—
0
0
0
12
0.00
0.22
0.0
1.3
—
—
—
0
0
0
12
0.00
0.22
0.0
1.3
—
—
—
0
0
0
12
0.00
0.22
0.0
1.3
—
—
—
0
0
0
12
0.00
0.22
0.0
1.3
—
—
—
0
0
0
12
0.00
0.22
0.0
1.2
—
—
—
0
0
0
12
0.00
0.22
0.0
1.3
—
—
—
0
0
5
44
1.22
0.12
1.0
1.9
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
13
122
+∞
-0.00
50.5
12.9
5.45
6.99
e9/l
1.12
13
115
13
122
+∞
-0.00
50.5
12.8
238.23
268.54
e9/l
0.79
13
116
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
13
122
+∞
-0.00
50.5
12.8
4.00
4.51
e12/l
2.39
13
115
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_MEDULLOBLASTOMA_WIDE – Brain medulloblastoma, including Hilmo

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).